Serine/threonine-Protein Kinase Pak 4

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Serine/threonine-Protein Kinase Pak 4
  Conformer 1
(PDB) 		2cdz (A)
  Conformer 2
(PDB) 		2bva (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 214 0.94   303 - 314   364 - 379   397 - 585
2 51 2.48   315 - 363   380 - 396

Sequence


           __________311________________________________________354______________________379______________396______________________ 
 2cdz(A) : VSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVR--gKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIA 
         :                                                                                                                          
 2bva(A) : *SHEQFRAALQLVVDPGDPRSYLDNFIKIG-----iVCIATVRSSGKLVAVKKMDl--------LFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIA 
           __________311________________________________________362______________________379______________396______________________ 

           ________________________________________________________________________________________________________________________ 
 2cdz(A) : AVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKlVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLH 
         :                                                                                                                          
 2bva(A) : AVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQV--eVPRRKlVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLH 
           ________________________________________________________________________________________________________________________ 

           ___________________________________________________                                                                      
 2cdz(A) : KVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRT                                                                      
         :                                                                                                                          
 2bva(A) : KVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQ***                                                                      
           ___________________________________________________                                                                      

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		21.9
Translation
(A) 		0.7
Closure
(%) 		96.4
Bending Residues
( green ) 		  311 - 315
  354 - 372
  379 - 380
  396 - 397
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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