Tyrosine-Protein Kinase Syk

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Tyrosine-Protein Kinase Syk
  Conformer 1
(PDB) 		1xbb (A)
  Conformer 2
(PDB) 		1xbc (A)
  Window Length 9
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 227 0.48   367 - 370   372 - 375   401 - 629
2 26 0.56   371 - 371   376 - 400

Sequence


           _____370___________________________400__________________________________________________________________________________ 
 1xbb(A) : VYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKpALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE 
         :                                                                                                                          
 1xbc(A) : VYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKIL-pALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEE 
           _____370___________________________400__________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 1xbb(A) : SNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKA----kWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNL 
         :                                                                                                                          
 1xbc(A) : SNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNL 
           ________________________________________________________________________________________________________________________ 

           ________________________________                                                                                         
 1xbb(A) : CWTYDVENRPGFAAVELRLRNYYYDVVNEGHH                                                                                         
         :                                                                                                                          
 1xbc(A) : CWTYDVENRPGFAAVELRLRNYYYDVVNE***                                                                                         
           ________________________________                                                                                         

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		5.1
Translation
(A) 		0.0
Closure
(%) 		60.7
Bending Residues
( green ) 		  370 - 376
  400 - 401
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Mixed

PyMOL Script

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