DynDom - Protein Domain Motions

Vitamin D Hydroxylase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Vitamin D Hydroxylase
Conformer 1 (PDB)	3a4z (A)
Conformer 2 (PDB)	3a4h (A)
Window Length	15
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	306	0.73	11 - 100 104 - 147 225 - 396
2	80	2.85	101 - 103 148 - 224

Sequence

`_______________________________________________________________________________________________98__103__________________` `3a4z(A) : ALTTTGTEQHDLFSGTFWQNPHPAYAALRAEDPVRKLALPDGPVWLLTRYADVREAFVDPRLSKDWRHRLPEDQRADMPATPTPMMILMDPPDHTRLRKLVGRSFTVRRMNELEPRITEI` `:` `3a4h(A) : **TTTGTEQHDLFSGTFWQNPHPAYAALRAEDPVRKLALPDGPVWLLTRYADVREAFVDPRLSKDWRHTLPEDQRADMPATPTPMMILMDPPDHTRLRKLVGRSFTVRRMNELEPRITEI` `_______________________________________________________________________________________________98__103__________________` `______________________146___________________________________________________________________________224_________________` `3a4z(A) : ADGLLAGLPTDGPVDLMREYAFQIPVQVICELLGLPAEDRDDFSAWSSVLVDDSPADDKNAAMGKLHGYLSDLLERKRTEPDDALLSSLLAVSDMDGDRLSQEELVAMAMLLLIAGHETT` `:` `3a4h(A) : ADGLLAGLPTDGPVDLMREYAFQIPVQVICELLGVPAEDRDDFSAWSSVLVDDSPADDKNAAMGKLHGYLSDLLERKRTEPDDALLSSLLAVSDEDGDRLSQEELVAMAMLLLIAGHETT` `______________________146___________________________________________________________________________224_________________` `________________________________________________________________________________________________________________________` `3a4z(A) : VNLIGNGVLALLTHPDQRKLLAEDPSLISSAVEEFLRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWMPEPDRLDITRDASGGVFFGHGIHFCLGAQLARLEGRVAI` `:` `3a4h(A) : VNLIGNGVLALLTHPDQRKLLAEDPSLISSAVEEFLRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWMPEPDRLDITRDASGGVFFGHGIHFCLGAQLARLEGRVAI` `________________________________________________________________________________________________________________________` `__________________________________________` `3a4z(A) : GRLFADRPELALAVGLDELVYRRSTLVRGLSRMPVTMGPRSA` `:` `3a4h(A) : GRLFADRPELALAVGLDELVYRESTLVRGLSRMPVTMGPRSA` `__________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	13.9
Translation (A)	-2.7
Closure (%)	63.1
Bending Residues ( green )	98 - 101 103 - 115 146 - 148 224 - 244
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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