Receptor Tyrosine-Protein Kinase Erbb-4

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Receptor Tyrosine-Protein Kinase Erbb-4
  Conformer 1
(PDB) 		3u2p (A)
  Conformer 2
(PDB) 		3u7u (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 32 0.93   265 - 268   273 - 305
2 42 1.39   226 - 264   269 - 271
3 188 0.43   308 - 495
4 210 2.02   3 - 225

Sequence


           ________________________________________________________________________________________________________________________ 
 3u2p(A) : QSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNG 
         :                                                                                                                          
 3u7u(A) : QSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNG 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________225_____________________ 
 3u2p(A) : GVYVDQNKFLCYADTIHWQDIVRNPs-------GCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPT 
         :                                                                                                                          
 3u7u(A) : GVYVDQNKFLCYADTIHWQDIVRNPsNLTLVSsGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPT 
           ________________________________________________________________________________________________225_____________________ 

           _______________264______________________________________305_____________________________________________________________ 
 3u2p(A) : TFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEV-----kMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNV 
         :                                                                                                                          
 3u7u(A) : TFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNV 
           _______________264______________________________________305_____________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 3u2p(A) : FRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDG 
         :                                                                                                                          
 3u7u(A) : FRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDG 
           ________________________________________________________________________________________________________________________ 

           ______________________________________________________________________                                                   
 3u2p(A) : CWGPGPDQCLS***********************************************************                                                   
         :                                                                                                                          
 3u7u(A) : CWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENDSICVECDPQCEKMEDGLLTCHGPGPDNCTKCS                                                   
           ______________________________________________________________________                                                   

Morph

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Domain Pairs

Fixed Domain Moving Domain Rotation Angle Translation   (A) Closure Bending Residues  
1 2 25.9 -0.1 30.1   264 - 265   267 - 273 Bending Region Analysis
1 3 113.6 1.4 86.5   305 - 308 Bending Region Analysis
4 2 17.6 -0.7 95.6   225 - 226 Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification:

No Contacts

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 4 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 4

Movement classification: Hinge

PyMOL Script

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