DynDom - Protein Domain Motions

Bifunctional Sat/aps Kinase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Bifunctional Sat/aps Kinase
Conformer 1 (PDB)	2gks (B)
Conformer 2 (PDB)	2gks (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	331	0.52	6 - 304 307 - 317 339 - 339 342 - 344 349 - 365
2	187	2.32	305 - 306 318 - 338 340 - 341 345 - 348 366 - 544

Sequence

`________________________________________________________________________________________________________________________` `2gks(B) : KIKYLKSIQISQRSVLDLELLAVGAFTPLDRFMGEEDYRNVVESMRLKSGTLFPIPITLPMEKEIAKDLKEGEWIVLRDPKNVPLAIMRVEEVYKWNLEYEAKNVLGTTDPRHPLVAEMH` `:` `2gks(A) : *IKYLKSIQISQRSVLDLELLAVGAFTPLDRFMGEEDYRNVVESMRLKSGTLFPIPITLPMEKEIAKDLKEGEWIVLRDPKNVPLAIMRVEEVYKWNLEYEAKNVLGTTDPRHPLVAEMH` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2gks(B) : TWGEYYISGELKVIQLPKYYDFPEYRKTPKQVREEIKSLGLDKIVAFQTRNPMHRVHEELTKRAMEKVGGGLLLHPVVGLTKPGDVDVYTRMRIYKVLYEKYYDKKKTILAFLPLAMRMA` `:` `2gks(A) : TWGEYYISGELKVIQLPKYYDFPEYRKTPKQVREEIKSLGLDKIVAFQTRNPMHRVHEELTKRAMEKVGGGLLLHPVVGLTKPGDVDVYTRMRIYKVLYEKYYDKKKTILAFLPLAMRMA` `________________________________________________________________________________________________________________________` `___________________________________________________________304__________317___338_______348______________365____________` `2gks(B) : GPREALWHGIIRRNYGATHFIVGRDHASPGKDSKGKPFYDPYEAQELFKKYEDEIGIKMVPFEELVYVPELDQYVEINEiRENFLKQGRKLPEWFTRPEVAEILAETYVPKHKQGFCVWL` `:` `2gks(A) : GPREALWHGIIRRNYGATHFIVGRDHASPGKDSKGKPFYDPYEAQELFKKYEDEIGIKMVPFEELVYVPELDQYVEINEiRENFLKQGRKLPEWFTRPEVAEILAETYVPKHKQGFCVWL` `___________________________________________________________304__________317___338_______348______________365____________` `________________________________________________________________________________________________________________________` `2gks(B) : TGLPCAGKSTIAEILATMLQARGRKVTLLDGDVVRTHLSRGLGFSKEDRITNILRVGFVASEIVKHNGVVICALVSPYRSARNQVRNMMEEGKFIEVFVDAPVEVCEERDVKGLYKKAKE` `:` `2gks(A) : TGLPCAGKSTIAEILATMLQARGRKVTLLDGDVVRTHLSRGLGFSKEDRITNILRVGFVASEIVKHNGVVICALVSPYRSARNQVRNMMEEGKFIEVFVDAPVEVCEERDVKGLYKKA--` `________________________________________________________________________________________________________________________` `_________________________________________________` `2gks(B) :` `GLIKGFTGVDDPYEPPVAPEVRVDTTKLTPEESALKILEFLKKEGFIKD` `:` `2gks(A) :` `----gFTGVDDPYEPPVAPEVRVDTTKLTPEESALKILEFLKKEGFIKD` `_________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	9.8
Translation (A)	0.3
Closure (%)	81.8
Bending Residues ( green )	304 - 307 317 - 318 338 - 345 348 - 352 365 - 366
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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