Heavy Chain Of A Vegf Binding Antibody

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Heavy Chain Of A Vegf Binding Antibody
  Conformer 1
(PDB)
2fjf (V)
  Conformer 2
(PDB)
1n8z (B)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 118 1.32   3 - 120
2 93 0.74   121 - 218

Sequence


           _____________________________________________________________________________________________________________________120 
 2fjf(V) : EVQLVESGGGLVQPGGSLRLSCAASGFTISDYWIHWVRQAPGKGLEWVAGITPAGGYTYYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARFVFFLPYAMDYWGQGTLVTVSS 
         :                                                                                                                          
 1n8z(B) : EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSS 
           _____________________________________________________________________________________________________________________120 

           _______________________________________________________________________________________________________                  
 2fjf(V) : ASTKGPSVFPLAPSS-----gTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC                  
         :                                                                                                                          
 1n8z(B) : ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP***                  
           _______________________________________________________________________________________________________                  

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
49.9
Translation
(A)
-0.4
Closure
(%)
98.0
Bending Residues
( green )
  120 - 126
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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