Hiv-1 Reverse Transcriptase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Hiv-1 Reverse Transcriptase
  Conformer 1
(PDB) 		1ep4 (B)
  Conformer 2
(PDB) 		1n5y (B)
  Window Length 9
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 231 1.28   37 - 57   78 - 80   82 - 129   144 - 235   326 - 420
2 63 1.2   9 - 36   58 - 77   81 - 81   130 - 143
3 77 1.01   236 - 310   422 - 423

Sequence


           __________________________________36___________________57__________________77_80________________________________________ 
 1ep4(B) : ****IETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFW-------hPAGLKKKKSVTVLDVGDAYFSVPL 
         :                                                                                                                          
 1n5y(B) : PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL 
           __________________________________36___________________57__________________77_80________________________________________ 

           ______129___________143_________________________________________________________________________________________235_____ 
 1ep4(B) : DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLT----------------yELHPDKWT 
         :                                                                                                                          
 1n5y(B) : DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT 
           ______129___________143_________________________________________________________________________________________235_____ 

           ___________________________________________________________________310__________________________________________________ 
 1ep4(B) : VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAR---- 
         :                                                                                                                          
 1n5y(B) : VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLSKLLRGTKALTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA 
           ___________________________________________________________________310__________________________________________________ 

           _________________________________________________________420_________                                                    
 1ep4(B) : -tNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWY**                                                    
         :                                                                                                                          
 1n5y(B) : HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQL                                                    
           _________________________________________________________420_________                                                    

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		11.3
Translation
(A) 		-0.4
Closure
(%) 		61.6
Bending Residues
( green ) 		  36 - 37
  57 - 58
  77 - 78
  80 - 85
  129 - 130
  143 - 144
Bending Region Analysis
Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( yellow ) 		3
Rotation Angle
(deg) 		8.5
Translation
(A) 		-1.4
Closure
(%) 		50.7
Bending Residues
( green ) 		  235 - 236
  310 - 326
  420 - 423
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Shear

PyMOL Script

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