Importin Alpha Subunit

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Importin Alpha Subunit
  Conformer 1
(PDB)
1wa5 (B)
  Conformer 2
(PDB)
1ee5 (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 253 0.7   245 - 245   249 - 254   261 - 270   273 - 508
2 164 0.69   92 - 244   246 - 248   255 - 260   271 - 272

Sequence


           ________________________________________________________________________________________________________________________ 
 1wa5(B) : fVPEYRRTeLRRRRDTQQVELRKAKRDEALAKRRNFqELPQMTQQLNSDDMQEQLSATVKFRQILSREHRPPIDVVIQAGVVPRLVEFMRENQPEMLQLEAAWALTNIASGTSAQTKVVV 
         :                                                                                                                          
 1ee5(A) : ***************************************PQMTQQLNSDDMQEQLSATVKFRQILSREHRPPIDVVIQAGVVPRLVEFMRENQPEMLQLEAAWALTNIASGTSAQTKVVV 
           ________________________________________________________________________________________________________________________ 

           _______________________________________________________________________244_248___254___260______269_____________________ 
 1wa5(B) : DADAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSNKPSLIRTATWTLSNLCRGKKPQPDWSVVSQALPTLAKLIYSMDTETLVDACWAISYLSDGPQE 
         :                                                                                                                          
 1ee5(A) : DADAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSNKPSLIRTATWTLSNLCRGKKPQPDWSVVSQALPTLAKLIYSMDTETLVDACWAISYLSDGPQE 
           _______________________________________________________________________244_248___254___260______269_____________________ 

           ________________________________________________________________________________________________________________________ 
 1wa5(B) : AIQAVIDVRIPKRLVELLSHESTLVQTPALRAVGNIVTGNDLQTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPPLVKLLEVAEYKTKKEACWAISNA 
         :                                                                                                                          
 1ee5(A) : AIQAVIDVRIPKRLVELLSHESTLVQTPALRAVGNIVTGNDLQTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPPLVKLLEVAEDKTKKEACWAISNA 
           ________________________________________________________________________________________________________________________ 

           _______________________________________________________________________________________________________                  
 1wa5(B) : SSGGLQRPDIIRYLVSQGCIKPLCDLLEIADNRIIEVTLDALENILKMGEADKEARGLNINENADFIEKAGGMEKIFNCQQNENDKIYEKAYKIIETYFGEEE                  
         :                                                                                                                          
 1ee5(A) : SSGGLQRPDIIRYLVSQGCIKPLCDLLEIADNRIIEVTLDALENILKMGEADKEARGLNINENADFIEKAGGMEKIFNCQQNENDKIYEKAYKIIETYFG***                  
           _______________________________________________________________________________________________________                  

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
7.6
Translation
(A)
-0.2
Closure
(%)
96.4
Bending Residues
( green )
  244 - 246
  248 - 249
  254 - 255
  260 - 261
  269 - 273
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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