Importin Beta-1 Subunit

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Importin Beta-1 Subunit
  Conformer 1
(PDB)
2bku (D)
  Conformer 2
(PDB)
2bku (B)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 98 0.36   189 - 189   196 - 273   299 - 315   324 - 325
2 185 0.34   3 - 188   193 - 195
3 326 0.37   274 - 298   316 - 323   326 - 597   602 - 629
4 67 0.4   598 - 601   630 - 668   673 - 673   677 - 699
5 166 0.3   669 - 672   674 - 676   701 - 859

Sequence


           ________________________________________________________________________________________________________________________ 
 2bku(D) : MSTAEFAQLLENSILSPDQNIRLTSETQLKKLSNDNFLQFAGLSSQVLIDENTKLEGRILAALTLKNELVSKDSVKTQQFAQRWITQVSPEAKNQIKTNALTALVSIEPRIANAAAQLIA 
         :                                                                                                                          
 2bku(B) : MSTAEFAQLLENSILSPDQNIRLTSETQLKKLSNDNFLQFAGLSSQVLIDENTKLEGRILAALTLKNELVSKDSVKTQQFAQRWITQVSPEAKNQIKTNALTALVSIEPRIANAAAQLIA 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________187_____________________________________________________ 
 2bku(D) : AIADIELPHGAWPELMKIMVDNTGAEQPENVKRASLLALGYMCESADPQSQALVSSSNNILIAIVQGAQSTETSKAVRLAALNALADSLIFIKNNMEREGERNYLMQVVCEATQAEDIEV 
         :                                                                                                                          
 2bku(B) : AIADIELPHGAWPELMKIMVDNTGAEQPENVKRASLLALGYMCESAD----aLVSSSNNILIAIVQGAQSTETSKAVRLAALNALADSLIFIKNNMEREGERNYLMQVVCEATQAEDIEV 
           ________________________________________________________________187_____________________________________________________ 

           _____________________________272_______________________298______________315_____323_____________________________________ 
 2bku(D) : QAAAFGCLCKIMSKYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTICEEEIDIAYELAQFPQSPLQSYNFALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFAQ 
         :                                                                                                                          
 2bku(B) : QAAAFGCLCKIMSKYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTICEEEIDIAYELAQFPQSPLQSYNFALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFAQ 
           _____________________________272_______________________298______________315_____323_____________________________________ 

           ________________________________________________________________________________________________________________________ 
 2bku(D) : NCGNHILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIINL 
         :                                                                                                                          
 2bku(B) : NCGNHILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIINL 
           ________________________________________________________________________________________________________________________ 

           __________________________________________________________________________________________________________________597_60 
 2bku(D) : VEQLAEATPSPIYNFYPALVDGLIGAANRIDNEFNARASAFSALTTMVEYATDTVAETSASISTFVMDKLGQTMSV-------eDAQSLQELQSNILTVLAAVIRKSPSSVEPVADMLMG 
         :                                                                                                                          
 2bku(B) : VEQLAEATPSPIYNFYPALVDGLIGAANRIDNEFNARASAFSALTTMVEYATDTVAETSASISTFVMDKLGQTMSVDENQLTLEDAQSLQELQSNILTVLAAVIRKSPSSVEPVADMLMG 
           __________________________________________________________________________________________________________________597_60 

           1_________________________629____________________________________668____________________________699_____________________ 
 2bku(D) : LFFRLLEKKDSAFIEDDVFYAISALAASLGKGFEKYLETFSPYLLKALNQVDSPVSITAVGFIADISNSLEEDFRRYSDAMMNVLAQMISNPNARRELKPAVLSVFGDIASNIGADFIPY 
         :                                                                                                                          
 2bku(B) : LFFRLLEKKDSAFIEDDVFYAISALAASLGKGFEKYLETFSPYLLKALNQVDSPVSITAVGFIADISNSLEEDFRRYSDAMMNVLAQMISNPNARRELKPAVLSVFGDIASNIGADFIPY 
           1_________________________629____________________________________668____________________________699_____________________ 

           ________________________________________________________________________________________________________________________ 
 2bku(D) : LNDIMALCVAAQNTKPENGTLEALDYQIKVLEAVLDAYVGIVAGLHDKPEALFPYVGTIFQFIAQVAEDPQLYSEDATSRAAVGLIGDIAAMFPDGSIKQFYGQDWVIDYIKRTRSGQLF 
         :                                                                                                                          
 2bku(B) : LNDIMALCVAAQNTKPENGTLEALDYQIKVLEAVLDAYVGIVAGLHDKPEALFPYVGTIFQFIAQVAEDPQLYSEDATSRAAVGLIGDIAAMFPDGSIKQFYGQDWVIDYIKRTRSGQLF 
           ________________________________________________________________________________________________________________________ 

           _____________________                                                                                                    
 2bku(D) : SQATKDTARWAREQQKRQLSL                                                                                                    
         :                                                                                                                          
 2bku(B) : SQATKDTARWAREQQKRQLSL                                                                                                    
           _____________________                                                                                                    

Morph

Morph animation in progress.
Status: Initialising

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Fixed Domain Moving Domain Rotation Angle Translation   (A) Closure Bending Residues  
1 2 4.5 0.2 99.9   187 - 196 Bending Region Analysis
1 3 3.9 0.1 85.7   272 - 274   298 - 299   315 - 316   323 - 326 Bending Region Analysis
4 3 3.9 -0.1 5.4   597 - 598   601 - 602   629 - 630 Bending Region Analysis
4 5 6.0 0.0 77.3   668 - 669   671 - 677   699 - 703 Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 4 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 4

Movement classification: Hinge

Conformer 1 Contact:
Residue 4 ———› Residue 5

Conformer 2 Contact:
Residue 5 ———› Residue 4

Movement classification: Hinge

PyMOL Script

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