Importin Beta-1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Importin Beta-1
  Conformer 1
(PDB)
1f59 (B)
  Conformer 2
(PDB)
1gcj (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 251 1.16   125 - 134   168 - 179   198 - 200   203 - 438
2 173 0.66   3 - 124   135 - 167   180 - 197   201 - 202

Sequence


           ________________________________________________________________________________________________________________________ 
 1f59(B) : *****MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQIKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLHTLGTETYRPSSASQCVAG 
         :                                                                                                                          
 1gcj(A) : PDYASGeLITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQIKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTETYRPSSASQCVAG 
           ________________________________________________________________________________________________________________________ 

           ______124__129___________________________________167_________179_______________197______________________________________ 
 1f59(B) : IACAEIPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRV 
         :                                                                                                                          
 1gcj(A) : IACAEIPVSQWPELIPQLVANVTNPNSTEH-kESTLEAIGYICQDIDPEQLQDKSNEILTAIIQG-rKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFI-qVVCEATQCPDTRVRV 
           ______124__129___________________________________167_________179_______________197______________________________________ 

           ________________________________________________________________________________________________________________________ 
 1f59(B) : AALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLL 
         :                                                                                                                          
 1gcj(A) : AALQNLVKI-sLYYQY-eTY-gPALFAITIEA-kSDIDEVALQGIEFWSNVCDEE-dLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCL-lL 
           ________________________________________________________________________________________________________________________ 

           ___________________________________________________________________________________________________                      
 1f59(B) : ATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLP**************                      
         :                                                                                                                          
 1gcj(A) : STCCEDDIVPHVLPFIKEHIKNPDWRYRDAAV-aFGSILEGPEPNQLKPLVIQA-pTLIEL-kDPSVVVRDTTAWTVGRICELLPEAAINDVYLVPNSS                      
           ___________________________________________________________________________________________________                      

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
12.0
Translation
(A)
-0.3
Closure
(%)
82.8
Bending Residues
( green )
  124 - 125
  129 - 135
  167 - 168
  179 - 180
  197 - 198
  200 - 203
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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