DynDom - Protein Domain Motions

Cystathionine Beta-Synthase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Cystathionine Beta-Synthase
Conformer 1 (PDB)	4pcu (A)
Conformer 2 (PDB)	4pcu (B)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	350	0.39	45 - 396
2	128	1.75	397 - 543

Sequence

`________________________________________________________________________________________________________________________` `4pcu(A) : WIRPDAPSRCTWQLGRPASESPHHHTAPAKSPKILPDILKKIGDTPMVRINKIGKKFGLKCELLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPGDTIIEPTSGNTGIGLALAAAVRG` `:` `4pcu(B) : WIRPDAPSRCTWQLGRPASESPHHHTAPAKSPKILPDILKKIGDTPMVRINKIGKKFGLKCELLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPGDTIIEPTSGNTGIGLALAAAVRG` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `4pcu(A) : YRCIIVMPEKMSSEKVDVLRALGAEIVRTP--aRFDSPSSHVGVAWRLKNEIPNSHILDQYRNASNPLAHYDTTADEILQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCRIIGVDP` `:` `4pcu(B) : YRCIIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDSPSSHVGVAWRLKNEIPNSHILDQYRNASNPLAHYDTTADEILQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCRIIGVDP` `________________________________________________________________________________________________________________________` `______________________________________________________________________________________________________________395_______` `4pcu(A) : EGSILAEPEELNQTEQTTYEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTFARMLIAQEGLLCGGSAGSTVAVAVKAAQELQEGQRCVVILPDSVRNYMTKFLSDRWMLQKGFLKEEDL` `:` `4pcu(B) : EGSILAEPEELNQTEQTTYEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTFARMLIAQEGLLCGGSAGSTVAVAVKAAQELQEGQRCVVILPDSVRNYMTKFLSDRWMLQKGFLKEED-` `______________________________________________________________________________________________________________395_______` `________________________________________________________________________________________________________________________` `4pcu(A) :` `kKPWWWHLRVQELGLSAPLTVLPTITCGHTIEILREKGFDQAPVVDEAGVILGMVTLGNMLSSLLAGKVQPSDQVGKVIYKQFKQIRLTDTLGRLSHILEMDHFALVVHEq---MVFGVV` `:` `4pcu(B) :` `---wWWHLRVQELGLSAPLTVLPTITCGHTIEILREKGFDQAPVVDEAGVILGMVTLGNMLSSLLAGKVQPSDQVGKVIYKQFKQIRLTDTLGRLSHILEMDHFALVVHEQqRQMVFGVV` `________________________________________________________________________________________________________________________` `_____________` `4pcu(A) : TAIDLLNFVAA**` `:` `4pcu(B) : TAIDLLNFVAAQE` `_____________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	48.0
Translation (A)	1.6
Closure (%)	98.6
Bending Residues ( green )	395 - 409
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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