Cystic Fibrosis Transmembrane Conductance Regulator

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Cystic Fibrosis Transmembrane Conductance Regulator
  Conformer 1
(PDB)
5w81 (A)
  Conformer 2
(PDB)
5uar (A)
  Window Length 9
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 664 2.1   5 - 227   326 - 847   922 - 935   1003 - 1005   1009 - 1146
2 476 2.92   228 - 325   848 - 921   936 - 1002   1006 - 1008   1147 - 1433

Sequence


           ________________________________________________________________________________________________________________________ 
 5w81(A) : MQRSPVEDANCLSRYFFWWTNPIMRKGFKEKLRPSDVYQAPSQDAADILAERLEKEWDREVASGKKKPSLLRAMARCYIKPFLLFGFLLYIGEATKTVQPQLLGRIIASFDPAHEPERAN 
         :                                                                                                                          
 5uar(A) : MQRSPVEDANCLSRYFFWWTNPIMRKGFKEKLRPSDVYQAPSQDAADILAERLEKEWDREVASGKKKPSLLRAMARCYIKPFLLFGFLLYIGEATKTVQPQLLGRIIASFDPAHEPERAN 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________227_____________ 
 5w81(A) : GYFLAFGLGLLFTARFLLLQPAMFGLHHLGMQIRIALFSIIYKKTLKLSSRVLDKISTGQLVSLMSANLGKFDQSLGMAHFIWISPLQCILCTGLIWELIDVNSFCALAAISLLGVLQAF 
         :                                                                                                                          
 5uar(A) : GYFLAFGLGLLFTARFLLLQPAMFGLHHLGMQIRIALFSIIYKKTLKLSSRVLDKISTGQLVSLMSANLGKFDQSLGMAHFIWISPLQCILCTGLIWELIDVNSFCALAAISLLGVLQAF 
           ________________________________________________________________________________________________________227_____________ 

           __________________________________________________________________________________325___________________________________ 
 5w81(A) : LSHKMGPYKAQKVLLTNKRLALTSEIMENLHSVKAYGWEEIMETLIKNIRQDEVKLTRKIGSLRYFYSSAYFFSAIFVIVAAVVPHALSRGINLRRIFTTLSYCMVLRMTVTRQLPGSIQ 
         :                                                                                                                          
 5uar(A) : LSHKMGPYKAQKVLLTNKRLALTSEIMENLHSVKAYGWEEIMETLIKNIRQDEVKLTRKIGSLRYFYSSAYFFSAIFVIVAAVVPHALSRGINLRRIFTTLSYCMVLRMTVTRQLPGSIQ 
           __________________________________________________________________________________325___________________________________ 

           ________________________________________________________________________________________________________________________ 
 5w81(A) : MWYDTMRLIWKIEEFLSKEEYKLMEYDLSITELELQDVTASWDEGaPVLKDISLKLKKGEMLAVTGSMGSGKSSLLMTILGELVPSSGKIRHSGRISYSSQTAWIMPGTIRDNILFGLTY 
         :                                                                                                                          
 5uar(A) : MWYDTMRLIWKIEEFLSKEEYKLMEYDLSITELELQDVTASW---aPVLKDISLKLKKGEMLAVTGSMGSGKSSLLMTILGELVPSSGKIRHSGRISYSSQTAWIMPGTIRDNILFGLTY 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 5w81(A) : DEYRYKSVVKACQLEEDLAALPEKDKTPMAEGGLNLSGGQKARVALARAVYRDADLYLLDAPFTHLDIATEKEIFDKCLCKLMASKTRILVTNKIEHLKRADKILLLHNGESFFYGTFPE 
         :                                                                                                                          
 5uar(A) : DEYRYKSVVKACQLEEDLAALPEKDKTPMAEGGLNLSGGQKARVALARAVYRDADLYLLDAPFTHLDIATEKEIFDKCLCKLMASKTRILVTNKIEHLKRADKILLLHNGESFFYGTFPE 
           ________________________________________________________________________________________________________________________ 

           __________________________________________847________________________________882________________________935_____________ 
 5w81(A) : LQSERPDFSS-------------------------------wNTYVRYVSNNKSLLYVLIFILFIAAIEIAGSVAGIFLITDEL-----tSSYYILYIYVATSESLLAMGFFRGLPFVHT 
         :                                                                                                                          
 5uar(A) : LQSERPDFSSLLLGLEAYDNISAERRCSILTETLHRVStTKWNTYVRYVSNNKSLLYVLIFILFIAAIEIAGSVAGIFLITDELWREEHtSSYYILYIYVATSESLLAMGFFRGLPFVHT 
           __________________________________________847________________________________882________________________935_____________ 

           __________________________________________________1002__1008____________________________________________________________ 
 5w81(A) : TITISKKLHQKMLHAVLSAPMSVLNTMKTGRIMNRFTKDMATIDDMLPLLMFDFVQLTVVVVGCILVVSIVRPYIFLAATPLAIIFIVMRKYFLRTGQQLKQLETEARSPIFSHLIMSLK 
         :                                                                                                                          
 5uar(A) : TITISKKLHQKMLHAVLSAPMSVLNTMKTGRIMNRFTKDMATIDDMLPLLMFDFVQLTVVVVGCILVVSIVRPYIFLAATPLAIIFIVMRKYFLRTGQQLKQLETEARSPIFSHLIMSLK 
           __________________________________________________1002__1008____________________________________________________________ 

           _______________________________________________________1127_____________________________________________________________ 
 5w81(A) : GLWTIRAFERQAYFEALFHKTLNTHTATWFLYLSTLRWFLFRADILFVFFFTLAAWIAVGTNQDKPGEIGIIICLAMLILGTFQWCVATSIAVDGMMRSVDRVFKFIDLPSETsSWPHRG 
         :                                                                                                                          
 5uar(A) : GLWTIRAFERQAYFEALFHKTLNTHTATWFLYLSTLRWFLFRADILFVFFFTLAAWIAVGTNQDKPGEIGIIICLAMLILGTFQWCVATSIAVDGMMRSVDRVFKFIDLPSE-sSWPHRG 
           _______________________________________________________1127_____________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 5w81(A) : QIEVRNLTVKYTEAGHAVLKNLSFSAEGRQRVGILGRTGSGKSSLFNALLKLVYTDGEISIDGVNWNKMPLQKWRKAFGVVPQKVFIFTGPLRMNLDPYGCHSDEELWRVAEEVGLKTVI 
         :                                                                                                                          
 5uar(A) : QIEVRNLTVKYTEAGHAVLKNLSFSAEGRQRVGILGRTGSGKSSLFNALLKLVYTDGEISIDGVNWNKMPLQKWRKAFGVVPQKVFIFTGPLRMNLDPYGCHSDEELWRVAEEVGLKTVI 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 5w81(A) : EQFPDKLDFQLEYGGYVLSNGHKQLICLARSILSGARILLLDQPSAHLDPVTIKVLKKTLRQSFSTCTILLSEHKVEPLLECQSFLMMDKGQVKTYDSIQKLLNETSHLKQAISPAERLK 
         :                                                                                                                          
 5uar(A) : EQFPDKLDFQLEYGGYVLSNGHKQLICLARSILSGARILLLDEPSAHLDPVTIKVLKKTLRQSFSTCTILLSEHKVEPLLECQSFLMMDKGQVKTYDSIQKLLNETSH************ 
           ________________________________________________________________________________________________________________________ 

           _________                                                                                                                
 5w81(A) : LFPRRNSSM                                                                                                                
         :                                                                                                                          
 5uar(A) : *********                                                                                                                
           _________                                                                                                                

Morph

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Status: Initialising

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
18.2
Translation
(A)
-0.8
Closure
(%)
99.7
Bending Residues
( green )
  227 - 228
  325 - 326
  847 - 848
  882 - 932
  935 - 936
  1002 - 1003
  1005 - 1006
  1008 - 1009
  1127 - 1147
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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