DynDom - Protein Domain Motions

Bovine Multidrug Resistance Protein 1 (Mrp1),multidrug Resistance-Associated Protein 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Bovine Multidrug Resistance Protein 1 (Mrp1),multidrug Resistance-Associated Protein 1
Conformer 1 (PDB)	5uja (A)
Conformer 2 (PDB)	5uj9 (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	676	1.2	33 - 391 485 - 774 1010 - 1033 1035 - 1132 1136 - 1143
2	513	0.74	392 - 484 775 - 1009 1034 - 1034 1133 - 1135 1144 - 1412

Sequence

`________________________________________________________________________________________________________________________` `5uja(A) : XXXXXXXXXXXXXXXXXXXXXXXXxXXXXXXXXXXXXXXXXXXXXXXXXxXXXXXXXXXXXXXXXXXXXXXXXXXXXxXXXXXXXXXXXXXXXXXXXXXXXxXXXXXXXXXXXXXXXXXX` `:` `5uj9(A) : XXXXXXXXXXXXXXXXXXXXXXXXxXXXXXXXXXXXXXXXXXXXXXXXXxXXXXXXXXXXXXXXXXXXXXXXXXXXXxXXXXXXXXXXXXXXXXXXXXXXXxXXXXXXXXXXXXXXXXXX` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `5uja(A) : XXXXXpNPCPESSASFLSRITFWWITGMMVQGYRQPLESTDLWSLNKEDTSEQVVPVLVKNWKKECAKSfKVLYKTFGPYFLMSFLFKAVHDLMMFAGPEILKLLINFVNDKKAPEWQGY` `:` `5uj9(A) : XXXXXpNPCPESSASFLSRITFWWITGMMVQGYRQPLESTDLWSLNKEDTSEQVVPVLVKNWKKECAKSfKVLYKTFGPYFLMSFLFKAVHDLMMFAGPEILKLLINFVNDKKAPEWQGY` `________________________________________________________________________________________________________________________` `______________381____________________________________________________________________________________________________484` `5uja(A) : FYTALLFISACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNAARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPLNAVMA` `:` `5uj9(A) : FYTALLFISACLQTLVLHQYFHICFVSGMRIKTAVIGAVYRKALVITNAARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSVLAGVAVMVLMVPLNAVMA` `______________381____________________________________________________________________________________________________484` `________________________________________________________________________________________________________________________` `5uja(A) : MKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVYVTVDENNILDAQKAFVSLALFNILRFPLNILPMVIS` `:` `5uj9(A) : MKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLAAVGTFTWVCTPFLVALSTFAVYVTVDENNILDAQKAFVSLALFNILRFPLNILPMVIS` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `5uja(A) : SIVQASVSLKRLRVFLSHEDLDPDSIQRRsITVKNATFTWARNDPPTLHGITFSVPEGSLVAVVGQVGCGKSSLLSALLAEMDKVEGHVTVKGSVAYVPQQAWIQNISLRENILFGRQLQ` `:` `5uj9(A) : SIVQASVSLKRLRVFLSHEDLDPDSIQRRsITVKNATFTWARNDPPTLHGITFSVPEGSLVAVVGQVGCGKSSLLSALLAEMDKVEGHVTVKGSVAYVPQQAWIQNISLRENILFGRQLQ` `________________________________________________________________________________________________________________________` `______________________________________774_______________________________________________________________________________` `5uja(A) : ERYYKAVVEACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYCDSDVYLLDDPLSAVDAHVGKHIFENVIGPKGLLKNKTRLLVTHAISYLPQMDVIIVMSGGKISEMGSYQ` `:` `5uj9(A) : ERYYKAVVEACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYCDSDVYLLDDPLSAVDAHVGKHIFENVIGPKGLLKNKTRLLVTHAISYLPQMDVIIVMSGGKISEMGSYQ` `______________________________________774_______________________________________________________________________________` `________________________________________________________________1009____________________1033____________________________` `5uja(A) : ELLARDGAFAEFLRqVKLSVYWDYMKAIGLFISFLSIFLFLCNHVASLVSNYWLSLWTDDPIVNGTQEHTQVRLSVYGALGISQGITVFGYSMAVSIGGIFASRRLHLDLLHNVLRSPIS` `:` `5uj9(A) : ELLARDGAFAEFLRqVKLSVYWDYMKAIGLFISFLSIFLFLCNHVASLVSNYWLSLWTDDPIVNGTQEHTQVRLSVYGALGISQGITVFGYSMAVSIGGIFASRRLHLDLLHNVLRSPIS` `________________________________________________________________1009____________________1033____________________________` `___________________________________________________________________1132_______1143______________________________________` `5uja(A) : FFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFNVIGACIIILLATPMAAVIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIRQSDLKV` `:` `5uj9(A) : FFERTPSGNLVNRFSKELDTVDSMIPQVIKMFMGSLFNVIGACIIILLATPMAAVIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIRQSDLKV` `___________________________________________________________________1132_______1143______________________________________` `________________________________________________________________________________________________________________________` `5uja(A) : DENQKAYYPSIVANRWLAVRLECVGNCIVLFASLFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQDMAPPKDWPQVGRVEFRDYGLRY` `:` `5uj9(A) : DENQKAYYPSIVANRWLAVRLECVGNCIVLFASLFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQDMAPPKDWPQVGRVEFRDYGLRY` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `5uja(A) : REDLDLVLKHINVTIDGGEKVGIVGRTGAGKSSLTLGLFRIKESAEGEIIIDDINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKGFVSALPDKLNHE` `:` `5uj9(A) : REDLDLVLKHINVTIDGGEKVGIVGRTGAGKSSLTLGLFRIKESAEGEIIIDDINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKGFVSALPDKLNHE` `________________________________________________________________________________________________________________________` `_______________________________________________________________________________________________` `5uja(A) : CAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFDDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEWGSPSDLLQQ` `:` `5uj9(A) : CAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFDDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEWGSPSDLLQQ` `_______________________________________________________________________________________________`

Morph

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Status: Initialising

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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	13.5
Translation (A)	-0.5
Closure (%)	99.9
Bending Residues ( green )	381 - 393 484 - 485 774 - 775 1009 - 1010 1033 - 1035 1132 - 1133 1135 - 1136 1143 - 1145
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

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