DynDom - Protein Domain Motions

Cystathionine Beta-Synthase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Cystathionine Beta-Synthase
Conformer 1 (PDB)	4coo (A)
Conformer 2 (PDB)	4pcu (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	65	1.81	401 - 421 484 - 484 486 - 543
2	351	1.03	45 - 397
3	63	1.54	422 - 483 485 - 485

Sequence

`________________________________________________________________________________________________________________________` `4coo(A) : WIRPDAPSRCTWQLGRPASESPHHHTAPAKSPKILPDILKKIGDTPMVRINKIGKKFGLKCELLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPGDTIIEPTSGNTGIGLALAAAVRG` `:` `4pcu(A) : WIRPDAPSRCTWQLGRPASESPHHHTAPAKSPKILPDILKKIGDTPMVRINKIGKKFGLKCELLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPGDTIIEPTSGNTGIGLALAAAVRG` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `4coo(A) : YRCIIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILDQYRNASNPLAHYDTTADEILQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCRIIGVDP` `:` `4pcu(A) : YRCIIVMPEKMSSEKVDVLRALGAEIVRTP--aRFDSPSSHVGVAWRLKNEIPNSHILDQYRNASNPLAHYDTTADEILQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCRIIGVDP` `________________________________________________________________________________________________________________________` `_______________________________________________________________________________________________________________396______` `4coo(A) : EGSILAEPEELNQTEQTTYEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTFARMLIAQEGLLCGGSAGSTVAVAVKAAQELQEGQRCVVILPDSVRNYMTKFLSDRWMLQKGFLKEEDL` `:` `4pcu(A) : EGSILAEPEELNQTEQTTYEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTFARMLIAQEGLLCGGSAGSTVAVAVKAAQELQEGQRCVVILPDSVRNYMTKFLSDRWMLQKGFLKEEDL` `_______________________________________________________________________________________________________________396______` `________________421___________________________________________________________483_______________________________________` `4coo(A) :` `TEKKPWWWHLRVQELGLSAPLTVLPTITCGHTIEILREKGFDQAPVVDEAGVILGMVTLGNMLSSLLAGKVQPSDQVGKVIYKQFKQIRLTDTLGRLSHILEMDHFALVVHEqMVFGVVT` `:` `4pcu(A) :` `--kKPWWWHLRVQELGLSAPLTVLPTITCGHTIEILREKGFDQAPVVDEAGVILGMVTLGNMLSSLLAGKVQPSDQVGKVIYKQFKQIRLTDTLGRLSHILEMDHFALVVHEqMVFGVVT` `________________421___________________________________________________________483_______________________________________` `_____________` `4coo(A) : AIDLLNFVAAQER` `:` `4pcu(A) : AIDLLNFVAA***` `_____________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	109.8
Translation (A)	5.8
Closure (%)	80.1
Bending Residues ( green )	396 - 405
Bending Region Analysis

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( yellow )	3
Rotation Angle (deg)	34.4
Translation (A)	0.9
Closure (%)	11.3
Bending Residues ( green )	421 - 422 483 - 486
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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