DynDom - Protein Domain Motions

Dengue 4 Ns3 Full-Length Protein

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Dengue 4 Ns3 Full-Length Protein
Conformer 1 (PDB)	2whx (A)
Conformer 2 (PDB)	5yvu (B)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	442	1.06	175 - 616
2	129	0.98	23 - 170

Sequence

`________________________________________________________________________________________________________________________` `2whx(A) : **********GVYRIMQRGLFGKTQVGVGIHMEGVFHTMWHVTRGSVICHE--rLEPSWADVRNDMISYGGGWRLGDKWDKEEDVQVLAIEPGKNPKHVQTKPGLF-----eIGAVTLDF` `:` `5yvu(B) : GALWDVPlSEGVYRIMQRG---kTQVGVGIHMEGVFHTMWHVTRGSVICHETGRLEPSWADVRNDMISYGGGWRLGDKWDKEEDVQVLAIEPGKNPKHVQTKPGLFKTLTGEIGAVTLDF` `________________________________________________________________________________________________________________________` `___________________________________168__________________________________________________________________________________` `2whx(A) : KPGTSGSPIINKKGKVIGLYGN---------vSAITQAERIGEPDYEVDEDIFRKKRLTIMDLHPGAGKTKRILPSIVREALKRRLRTLILAPTRVVAAEMEEALRGLPIRYQTPAVKSD` `:` `5yvu(B) : KPGTAGSPIINKKGKVIGLYGNGVVTKSGDYVSAITQAER----dYEVDEDIFRKKRLTIMDLHPGAGKTKRILPSIVREALKRRLRTLILAPTRVVAAEMEEALRGLPIRYQTPAVKSE` `___________________________________168__________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2whx(A) : HTGREIVDLMCHATFTTRLLSSTRVPNYNLIVMDEAHFTDPCSVAARGYISTRVEMGEAAAIFMTATPPGSTDPFPQSNSPIEDIEREIPERSWNTGFDWITDYQGKTVWFVPSIKAGND` `:` `5yvu(B) : HTGREIVDLMCHATFTTRLLSSTRVPNYNLIVMDEAHFTDPCSVAARGYISTRVEMGEAAAIFMTATPPGSIDPFPQSNSPIEDIEREIPERSWNTGFDWITDYQGKTVWFVPSIKAGND` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2whx(A) : IANCLRKSGKRVIQLSRKTFDTEYPKTKLTDWDFVVTTDISEMGANFRAGRVIDPRRCLKPVILTDGPERVILAGPIPVTPASAAQRRGRIGRNPAQEDDQYVFSGDPLKNDEDHAHWTE` `:` `5yvu(B) : IANCLRKSGKKVIQLSRKTFDTEYPKTKLTDWDFVVTTDISEMGANFRAGRVIDPRRCLKPVILTDGPERVILAGPIPVTPASAAQRRGRIGRNPAQEDDQYVFSGDPLKNDEDHAHWTE` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2whx(A) : AKMLLDNIYTPEGIIPTLFGPEREKTQAIDGEFRLRGEQRKTFVELMRRGDLPVWLSYKVASAGISYKDREWCFTGERNNQILEENMEVEIWTREGEKKKLRPKWLDARVYADPMALKDF` `:` `5yvu(B) : AKMLLDNIYTPEGIIPTLFGPEREKTQAIDGEFRLRGEQRKTFVELMRRGDLPVWLSYKVASAGISYKDREWCFTGERNNQILEENMEVEIWTREGEKKKLRPKWLDARVYADPMALKDF` `________________________________________________________________________________________________________________________` `________` `2whx(A) : KEFASGRK` `:` `5yvu(B) : KEFASGRK` `________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	144.7
Translation (A)	0.2
Closure (%)	14.6
Bending Residues ( green )	168 - 178
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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