Dicer

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Dicer
  Conformer 1
(PDB)
2ffl (B)
  Conformer 2
(PDB)
2ffl (D)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 422 0.63   277 - 291   296 - 301   305 - 313   321 - 329   334 - 386   388 - 672   677 - 752
2 288 0.41   3 - 276   292 - 295   302 - 304   314 - 320   330 - 333   387 - 387   673 - 676

Sequence


           ________________________________________________________________________________________________________________________ 
 2ffl(B) : AMHALGHCCTVVTTRGPSHWLLLLDTHLGTLPGFKVSAGRGLPAAEVYFEAGPRVSLSRTDATIVAVYQSILFQLLGPTFPASWTEIGATMPHNEYTFPRFISNPPQFATLAFLPLLSPT 
         :                                                                                                                          
 2ffl(D) : AMHALGHCCTVVTTRGPSHWLLLLDTHLGTLPGFKVSAGRGLPAAEVYFEAGPRVSLSRTDATIVAVYQSILFQLLGPTFPASWTEIGATMPHNEYTFPRFISNPPQFATLAFLPLLSPT 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 2ffl(B) : SPLDLRALMVTAQLMCDAKRLSDE----lSASLHGRMVATPEISWSLYVVLGIDSTQTSLSYFTRANESITYMRYYATAHNIHLRAADLPLVAAVRLDDLKDHQIPAPGSdDLAPKLRFL 
         :                                                                                                                          
 2ffl(D) : SPLDLRALMVTAQLMCDAKRLSDEYTDYlSASLHGRMVATPEISWSLYVVLGIDSTQTSLSYFTRANESITYMRYYATAHNIHLRAADLPLVAAVRLDDLKDHQIPAP--dDLAPKLRFL 
           ________________________________________________________________________________________________________________________ 

           _______________________________276____________291_295___301_________313____320______329_333_____________________________ 
 2ffl(B) : PPELCLLLPDEFDLIRVQALQFLPEIAKHICDIQNTICALDKSFPDCGRIGGERYFAITAGLRLDQGRGRGLAGWRTPFGPFGVSHTDVFQRLELLGDAVLGFIVTARLLCLFPDASVGT 
         :                                                                                                                          
 2ffl(D) : PPELCLLLPDEFDLIRVQALQFLPEIAKHICDIQNTICALDKSFPDCGRIGGERYFAITAGLRLDQGRGRGLAGWRTPFGPFGVSHTDVFQRLELLGDAVLGFIVTARLLCLFPDASVGT 
           _______________________________276____________291_295___301_________313____320______329_333_____________________________ 

           _____________________386________________________________________________________________________________________________ 
 2ffl(B) : LVELKMELVRNEALNYLVQTLGLPQLAEnNLVAKSKTWADMYEEIVGSIFTGPNGIYGCEEFLAKTLMSPEHSKTaCPDAVTKASKRVCMGEAGAHEFRSLVDYACEQGISVFCSSRVST 
         :                                                                                                                          
 2ffl(D) : LVELKMELVRNEALNYLVQTLGLPQLAEF-----sKTWADMYEEIVGSIFTGPNGIYGCEEFLAKTLMSPEHSKTaCPDAVTKASKRVCMGEAGAHEFRSLVDYACEQGISVFCSSRVST 
           _____________________386________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 2ffl(B) : MFLERLRDIPAEDMLDWYRLGIQFSHRSGLSGvSVIDIMTHLARGLWLGSPGFYVE-pPTIPVLYIYHRSVQCPVLYGSLTtGPVASKVLALYEKILAYESSGGSKHIAAQTVSRSLAVP 
         :                                                                                                                          
 2ffl(D) : MFLERLRDIPAEDMLDWYRLGIQFSHRSGLS-vSVIDIMTHLARGLWLGSPGFYVEQpPTIPVLYIYHRSVQCPVLYGSLTtGPVASKVLALYEKILAYE---gSKHIAAQTVSRSLAVP 
           ________________________________________________________________________________________________________________________ 

           ______________________________________________672_______________________________________________________________________ 
 2ffl(B) : IPSGTIPFLIRLLQIALTPHVYQKLELLGDAFLKCSLALHLHALHPTLTEGALTRMRQSAETNSVLGRLTKRFPSVVSEVIIESHPKIQPDSKVYGDTFEAILAAILLACGEEAAGAFVR 
         :                                                                                                                          
 2ffl(D) : IPSGTIPFLIRLLQIALTPHVYQKLELLGDAFLKCSLALHLHALHPTLTEGALTRMRQSAETNSVLGRLTKRFPSVVSEVIIESHPKIQPDSKVYGDTFEAILAAILLACGEEAAGAFVR 
           ______________________________________________672_______________________________________________________________________ 

           ___________                                                                                                              
 2ffl(B) : EHVLPQVVADA                                                                                                              
         :                                                                                                                          
 2ffl(D) : EHVLPQVVADA                                                                                                              
           ___________                                                                                                              

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
5.3
Translation
(A)
-0.3
Closure
(%)
7.4
Bending Residues
( green )
  276 - 277
  291 - 292
  295 - 296
  301 - 302
  304 - 305
  313 - 314
  320 - 321
  329 - 330
  333 - 334
  386 - 388
  672 - 673
  675 - 677
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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