Dual Specificity Mitogen-Activated Protein Kinase Kinase 2

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Dual Specificity Mitogen-Activated Protein Kinase Kinase 2
  Conformer 1
(PDB)
1s9i (A)
  Conformer 2
(PDB)
1s9j (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 263 0.87   67 - 77   99 - 388
2 21 0.81   78 - 98

Sequence


           ________________77___________________98_________________________________________________________________________________ 
 1s9i(A) : QKAKVGELKDDDFERISELGAGNGGVVTKVQHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKEAKRIPEEILGKVSIAVLR 
         :                                                                                                                          
 1s9j(A) : *****MELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIK 
           ________________73___________________94_________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 1s9i(A) : GLAYLREKHQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSM-vGTRSYMAPERLQGTHYSVQSDIWSMGLSLVELAVGRYPIPPPDAKELEAIFGRPVVDrPAMAIFELLDYIVNEP 
         :                                                                                                                          
 1s9j(A) : GLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMAvGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMF-------pPMAIFELLDYIVNEP 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________                                                         
 1s9i(A) : PPKLPNGVFTPDFQEFVNKCLIKNPAERADLKMLTNHTFIKRSEVEEVDFAGWLCKTLRLNQPG                                                         
         :                                                                                                                          
 1s9j(A) : PPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN***                                                         
           ________________________________________________________________                                                         

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
14.1
Translation
(A)
-0.4
Closure
(%)
16.2
Bending Residues
( green )
  77 - 78
  98 - 99
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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