Dual Specificity Mitogen-Activated Protein Kinase Kinase 6

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Dual Specificity Mitogen-Activated Protein Kinase Kinase 6
  Conformer 1
(PDB)
3fme (A)
  Conformer 2
(PDB)
3enm (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 199 2.5   82 - 83   110 - 115   118 - 331
2 33 3.84   48 - 81   116 - 117
3 21 2.07   84 - 109

Sequence


           __________________________________81_________________________109__114___________________________________________________ 
 3fme(A) : MEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR---nSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 
         :                                                                                                                          
 3enm(A) : FEVKADDLEPI-eLGRGAYGVVEK-rHVPSGQI-aVKRIRATVNSQEQKRLL-dLDIS-rTVDCPFTVTFYGALFREGDVWIC-eL-dTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKA 
           __________________________________81_________________________109__114___________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 3fme(A) : LEHLHSKLSVIHRDVKPSNVLINALGQVKMCDF--aGC----KPYMAPERINPELNQ--ySVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQC 
         :                                                                                                                          
 3enm(A) : LEHLHSKLSVIHRDVKPSNVLINALGQVK-cDFGISGYLVDDkPY-aPERINPELNQKGYSVKSDIWSLGIT-iELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQC 
           ________________________________________________________________________________________________________________________ 

           _______________________________________                                                                                  
 3fme(A) : LKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLILG                                                                                  
         :                                                                                                                          
 3enm(A) : LKKNSKERPTYPEL-qHPFFTLHESKGTDVASFVKLILA                                                                                  
           _______________________________________                                                                                  

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
59.7
Translation
(A)
0.0
Closure
(%)
39.9
Bending Residues
( green )
  81 - 83
  114 - 119
Bending Region Analysis
Property Value
Fixed Domain
( blue )
1
Moving Domain
( yellow )
3
Rotation Angle
(deg)
52.1
Translation
(A)
-1.9
Closure
(%)
90.3
Bending Residues
( green )
  82 - 84
  109 - 110
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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