DynDom - Protein Domain Motions

Elongation Factor G

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Elongation Factor G
Conformer 1 (PDB)	1fnm (A)
Conformer 2 (PDB)	1elo (A)
Window Length	9
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	395	2.04	10 - 125 130 - 153 160 - 437 450 - 450 452 - 460 463 - 479
2	227	1.45	126 - 129 154 - 159 438 - 449 451 - 451 461 - 462 480 - 684

Sequence

`__________________________________________________________________________________________125_129_____________________15` `1fnm(A) : EYDLKRLRNIGIAAHIDAGKTTTTERILYYTGRIaVTTCFWKDHRINIIDTPGHVDFTIEVERSMRVLDGAIVVFDSSQGVEPQSETVWRQAEKYKVPRIAFANKMDKTGADLWLVIRT` `:` `1elo(A) : VEYDLKRLRNIGIAAHIDAGKTTTTERILYYTGRIaVTTCFWKDHRINIIDTPGHVDFTIEVERSMRVLDGAIVVFDSSQGVEPQSETVWRQAEKYKVPRIAFANKMDKTGADLWLVIRT` `__________________________________________________________________________________________125_129_____________________15` `3___159_________________________________________________________________________________________________________________` `1fnm(A) : MQERLGARPVVMQLPIGREDTFSGIIDVLRMKAYTYGNDLGTDIREIPIPEEYLDQAREYHEKLVEVAADFDENIMLKYLEGEEPTEEELVAAIRKGTIDLKITPVFLGSALKNKGVQLL` `:` `1elo(A) : MQERLGARPVVMQLPIGREDTFSGIIDVLRMKAYTYGNDLGTDIREIPIPEEYLDQAREYHEKLVEVAADFDENIMLKYLEGEEPTEEELVAAIRKGTIDLKITPVFLGSALKNKGVQLL` `3___159_________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1fnm(A) : LDAVVDYLPSPLDIPPIKGTTPEGEVVEIHPDPNGPLAALAFKIMADPYVGRLTFIRVYSGTLTSGSYVYNTTKGRKERVARLLRMHANHREEVEELKAGDLGAVVGLKETITGDTLVGE` `:` `1elo(A) : LDAVVDYLPSPLDIPPIKGTTPEGEVVEIHPDPNGPLAALAFKIMADPYVGRLTFIRVYSGTLTSGSYVYNTTKGRKERVARLLRMHANHREEVEELKAGDLGAVVGLKETITGDTLVGE` `________________________________________________________________________________________________________________________` `__________________________________________437_________________457___________________479_________________________________` `1fnm(A) : DAPRVILESIEVPEPVIDVAIEPKTKADQEKLSQALARLAEEDPTFRVSTHPETGQTIISGMGELHLEIIVDRLKREFKVDANVGKPQVAYRETITKPVDVEGKFIRQTGGRGQYGHVKI` `:` `1elo(A) : DAPRVIL---------iDVAIEPK--------sQALARLAEEDPTFRVSTHP---qTIISGMGELHLEIIVDRLKREF-----vGKPQVAYRETITKPVDVEGKFIRQTGGRGQYGHVKI` `__________________________________________437_________________457___________________479_________________________________` `________________________________________________________________________________________________________________________` `1fnm(A) : KVEPLPRGSGFEFVNAIVGGVIPKEYIPAVQKGIEEAMQSGPLIGFPVVDIKVTLYDGSYAEVDSSEMAFKIAGSMAIKEAVQKGDPVILEPIMRVEVTTPEEYMGDVIGDLNARRGQIL` `:` `1elo(A) : KVEPLPRGSGFEFVNAIVGGVIPKEYIPAVQKGIEEAMQSGPLIGFPVVDIKVTLYDGSYHEVDSSEMAFKIAGSMAIKEAVQKGDPVILEPIMRVEVTTPEEYMGDVIGDLNARRGQIL` `________________________________________________________________________________________________________________________` `_________________________________________________________` `1fnm(A) : GMEPRGNAQVIRAFVPLAEMFGYATDLRSKTQGRGSFVMFFDHYQEVPKQVQEKLI` `:` `1elo(A) : GMEPRGNAQVIRAFVPLAEMFGYATDLRSKTQGRGSFVMFFDHYQEVPKQVQEKLIK` `_________________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	10.6
Translation (A)	1.4
Closure (%)	69.2
Bending Residues ( green )	125 - 126 129 - 130 153 - 154 159 - 160 437 - 452 457 - 463 479 - 480
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

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