Epidermal Growth Factor Receptor

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Epidermal Growth Factor Receptor
  Conformer 1
(PDB)
2gs2 (A)
  Conformer 2
(PDB)
2gs6 (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 257 0.45   677 - 684   704 - 719   731 - 756   768 - 988   992 - 992
2 35 0.54   685 - 703   720 - 721   757 - 767   989 - 991

Sequence


           _____________684________________703_____________719_______________________________756________767________________________ 
 2gs2(A) : ***GEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKEaTSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLL 
         :                                                                                                                          
 2gs6(A) : GAMGEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELtSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLL 
           _____________684________________703_____________719_______________________________756________767________________________ 

           ________________________________________________________________________________________________________________________ 
 2gs2(A) : NWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQ 
         :                                                                                                                          
 2gs6(A) : NWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQ 
           ________________________________________________________________________________________________________________________ 

           _____________________________________________________________988_______                                                  
 2gs2(A) : PPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLP--dMDDVVDADEYLI*                                                  
         :                                                                                                                          
 2gs6(A) : PPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSeDMDDVVDADEYLIP                                                  
           _____________________________________________________________988_______                                                  

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
4.0
Translation
(A)
-0.2
Closure
(%)
98.9
Bending Residues
( green )
  684 - 685
  703 - 704
  719 - 731
  756 - 757
  767 - 768
  988 - 989
  991 - 992
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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