3-Isopropylmalate Dehydrogenase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name 3-Isopropylmalate Dehydrogenase
  Conformer 1
(PDB)
2g4o (C)
  Conformer 2
(PDB)
1w0d (D)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 181 0.6   96 - 251   284 - 285   311 - 323   325 - 334
2 152 0.64   2 - 95   252 - 283   286 - 310   324 - 324

Sequence


           ______________________________________________________________________________________________95________________________ 
 2g4o(C) : MSKLAIIAGDGIGPEVTAEAVKVLDAVVPGVQKTSYDLGARRFHATGEVLPDSVVAELRNHDAILLGAIGDPSVPSGVLERGLLLRLRFELDHHINLRPARLYPGVASPLSGNPGIDFVV 
         :                                                                                                                          
 1w0d(D) : MSKLAIIAGDGIGPEVTAEAVKVLDAVVPGVQKTSYDLGARRFHATGEVLPDSVVAELRNHDAILLGAIGDPSVPSGVLERGLLLRLRFELDHHINLRPARLYPGVASPLSGNPGIDFVV 
           ______________________________________________________________________________________________95________________________ 

           ________________________________________________________________________________________________________________________ 
 2g4o(C) : VREGTEGPYTGNGGAIRVGTPNEVATEVSVNTAFGVRRVVADAFERARRRRKHLTLVHKTNVLTFAGGLWLRTVDEVGECYPDVEVAYQHVDAATIHMITDPGRFDVIVTDNLFGDIITD 
         :                                                                                                                          
 1w0d(D) : VREGTEGPYTGNGGAIRVGTPNEVATEVSVNTAFGVRRVVADAFERARRRRKHLTLVHKTNVLTFAGGLWLRTVDEVGECYPDVEVAYQHVDAATIHMITDPGRFDVIVTDNLFGDIITD 
           ________________________________________________________________________________________________________________________ 

           _________251_____________________________283________________________310__315_____________________                        
 2g4o(C) : LAAAVCGGIGLAASGNIDATRANPSMFEPVHGSAPDIAGQGIADPTAAIMSVALLLSHLGEHDAAARVDRAVEAHLATRGSERLATSDVGERIAAAL                        
         :                                                                                                                          
 1w0d(D) : LAAAVCGGIGLAASGNIDATRANPSMFEPVHGSAPDIAGQGIADPTAAIMSVALLLSHLGEHDAAARVDRAVEAHLATRGSERLATSDVGERIAAAL                        
           _________251_____________________________283________________________310__315_____________________                        

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
7.1
Translation
(A)
0.2
Closure
(%)
98.8
Bending Residues
( green )
  95 - 96
  251 - 252
  283 - 286
  310 - 311
  315 - 325
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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