Carboxyl-Terminal Src Kinase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Carboxyl-Terminal Src Kinase
  Conformer 1
(PDB)
1k9a (B)
  Conformer 2
(PDB)
1k9a (C)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 327 3.05   8 - 79   176 - 203   210 - 222   228 - 448
2 107 3.47   80 - 175   204 - 209   223 - 227

Sequence


           __________________________________________________________________________79____________________________________________ 
 1k9a(B) : IQASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCE 
         :                                                                                                                          
 1k9a(C) : **ASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCE 
           __________________________________________________________________________79____________________________________________ 

           _________________________________________________175_______________________201__________________________________________ 
 1k9a(B) : GKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQL 
         :                                                                                                                          
 1k9a(C) : GKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQL 
           _________________________________________________175_______________________201__________________________________________ 

           ________________________________________________________________________________________________________________________ 
 1k9a(B) : RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAgKLPVKWTAPEALREKKFSTKSDV 
         :                                                                                                                          
 1k9a(C) : RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAS-lPVKWTAPEALREKKFSTKSDV 
           ________________________________________________________________________________________________________________________ 

           _________________________________________________________________________________                                        
 1k9a(B) : WSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTHELHL                                        
         :                                                                                                                          
 1k9a(C) : WSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTHELHL                                        
           _________________________________________________________________________________                                        

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
47.6
Translation
(A)
3.5
Closure
(%)
78.5
Bending Residues
( green )
  79 - 80
  175 - 176
  201 - 235
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Mixed

PyMOL Script

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