10-Formyltetrahydrofolate Dehydrogenase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name 10-Formyltetrahydrofolate Dehydrogenase
  Conformer 1
(PDB)
1s3i (A)
  Conformer 2
(PDB)
2bw0 (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 187 0.71   104 - 175   191 - 305
2 116 0.85   3 - 103   176 - 190

Sequence


           ______________________________________________________________________________________________________103_______________ 
 1s3i(A) : **MKIAVIGQSLFGQEVYCQLRKEGHEVVGVFTIPDKDGKADPDGLEAEKDGVPVFKFPRWRARGQALPEVVAKYQALGAELNVLPFCSQFIPMEVINAPRHGSIIYHPSLLPRHRGASA 
         :                                                                                                                          
 2bw0(A) : QSMKIAVIGQSLFGQEVYCHLRKEGHEVVGVFTVPDKDGKADPLGLEAEKDGVPVFKYSRWRAKGQALPDVVAKYQALGAELNVLPFCSQFIPMEIISAPRHGSIIYHPSLLPRHRGASA 
           ______________________________________________________________________________________________________103_______________ 

           ______________________________________________________175____________190________________________________________________ 
 1s3i(A) : INWTLIHGDKKGGFTIFWADDGLDTGDLLLQKECEVLPDDTVSTLYNRFLFPEGIKGMVQAVRLIAEGTAPRCPQSEEGATYEGIQKKETAKINWDQPAEAIHNWIRGNDKVPGAWTEAC 
         :                                                                                                                          
 2bw0(A) : INWTLIHGDKKGGFSIFWADDGLDTGDLLLQKECEVLPDDTVSTLYNRFLFPEGIKGMVQAVRLIAEGKAPRLPQPEEGATYEGIQKKETAKINWDQPAEAIHNWIRGNDKVPGAWTEAC 
           ______________________________________________________175____________190________________________________________________ 

           _____________________________________________________________________                                                    
 1s3i(A) : GQKLTFFNSTLNTSGLSTQGEALPIPGAHRPGVVTKAGLILFGNDDRMLLVKNIQLEDGKMMPASQFFK                                                    
         :                                                                                                                          
 2bw0(A) : EQKLTFFNSTLNTSGLVPEGDALPIPGAHRPGVVTKAGLILFGNDDKMLLVKNIQLEDGKMILASNFFK                                                    
           _____________________________________________________________________                                                    

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
12.1
Translation
(A)
0.3
Closure
(%)
100.0
Bending Residues
( green )
  103 - 104
  175 - 176
  190 - 196
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Mixed

PyMOL Script

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