3-Isopropylmalate Dehydrogenase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name 3-Isopropylmalate Dehydrogenase
  Conformer 1
(PDB)
1v5b (A)
  Conformer 2
(PDB)
2ayq (B)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 177 0.72   28 - 31   104 - 134   136 - 263   265 - 266   311 - 322
2 174 0.64   3 - 27   32 - 103   135 - 135   264 - 264   267 - 310   323 - 353

Sequence


           _________________________27_________________________________________________________________________103_________________ 
 1v5b(A) : MKMKLAVLPGDGIGPEVMDAAIRVLKTVLDNDGHEAVFENALIGGAAIDEAGTPLPEETLDICRRSDAILLGAVGGPKWDHNPASLRPEKGLLGLRKEMGLFANLRPVKAYATLLNASPL 
         :                                                                                                                          
 2ayq(B) : MKMKLAVLPGDGIGPEVMDAAIRVLKTVLDNDGHEAVFENALIGGAAIDEAGTPLPEETLDICRRSDAILLGAVGGPKWDHNPASLRPEKGLLGLRKEMGLFANLRPVKAYATLLNASPL 
           _________________________27_________________________________________________________________________103_________________ 

           ___________134__________________________________________________________________________________________________________ 
 1v5b(A) : KRERVENVDLVIVRELTGGLYFGRPSERRGPGENEVVDTLAYTREEIERIIEKAFQLAQIRRKKLASVDKANVLESSRMWREIAEETAKKYPDVELSHMLVDSTAMQLIANPGQFDVIVT 
         :                                                                                                                          
 2ayq(B) : KRERVENVDLVIVRELTGGLYFGRPSERRGPGENEVVDTLAYTREEIERIIEKAFQLAQIRRKKLASVDKANVLESSRMWREIAEETAKKYPDVELSHMLVDSTSMQLIANPGQFDVIVT 
           ___________134__________________________________________________________________________________________________________ 

           ____________________263____________________________________________310_________322___________________________________    
 1v5b(A) : ENMFGDILSDLASVITGSLGMLPSASLRSDRFGMYEPVHGSAPDIAGQGKANPLGTVLSAALMLRYSFGLEKEAAAIEKAVDDVLQDGYCTGDLQVANGKVVSTIELTDRLIEKLN*    
         :                                                                                                                          
 2ayq(B) : ENMFGDILSDEASVITGSLGMLPSASLRSDRFGMYEPVHGSAPDIAGQGKANPLGTVLSAALMLRYSFGLEKEAAAIEKAVDDVLQDGYCTGDLQVANGKVVSTIELTDRLIEKLNN    
           ____________________263____________________________________________310_________322___________________________________    

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
6.7
Translation
(A)
0.1
Closure
(%)
58.1
Bending Residues
( green )
  27 - 35
  103 - 104
  134 - 136
  263 - 267
  310 - 311
  322 - 323
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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