DNA Topoisomerase I

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name DNA Topoisomerase I
  Conformer 1
(PDB)
1cyy (B)
  Conformer 2
(PDB)
1cyy (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 149 1.33   274 - 410   427 - 448
2 92 1.05   220 - 273   411 - 426   449 - 470

Sequence


           ________________________________________________________272_____________________________________________________________ 
 1cyy(B) : FVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVN 
         :                                                                                                                          
 1cyy(A) : ****EFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVN 
           ________________________________________________________272_____________________________________________________________ 

           __________________________________________________________________________410____________425_______________448__________ 
 1cyy(B) : MVRGYISDNFGKKYLPESPNQYAS-----eAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALdRILPAVNKGDA 
         :                                                                                                                          
 1cyy(A) : MVRGYISDNFGKKYLPESPNQYASKENSQEAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALdRILPAVNKGDA 
           __________________________________________________________________________410____________425_______________448__________ 

           ________________                                                                                                         
 1cyy(B) : LTLVELTPAQHFTKPP                                                                                                         
         :                                                                                                                          
 1cyy(A) : LTLVELTPAQHFTK**                                                                                                         
           ________________                                                                                                         

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
For more advanced options, right click on the model.


Show console


play backwards pause play forwards

Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
67.9
Translation
(A)
3.5
Closure
(%)
99.9
Bending Residues
( green )
  272 - 275
  410 - 411
  425 - 427
  448 - 449
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

Download and extract PyMOL PML script file Download