DNA Topoisomerase I

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name DNA Topoisomerase I
  Conformer 1
(PDB)
1r49 (A)
  Conformer 2
(PDB)
1k4t (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 481 1.07   206 - 645   706 - 763
2 60 0.71   646 - 705

Sequence


           ________________________________________________________________________________________________________________________ 
 1r49(A) : *KWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKCDFTQMSQYFKAQTEARKQMS 
         :                                                                                                                          
 1k4t(A) : QKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKFYYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKCDFTQMSQYFKAQTEARKQMS 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 1r49(A) : KEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCS-dAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKD 
         :                                                                                                                          
 1k4t(A) : KEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLFRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQGSIKYIMLNPSSRIKGEKD 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 1r49(A) : WQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGRDSIRYYNKVPVEKRVFKNLQLFMENKQP 
         :                                                                                                                          
 1k4t(A) : WQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYFIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNKVPVEKRVFKNLQLFMENKQP 
           ________________________________________________________________________________________________________________________ 

           _____________________________________________________________624________________________________________________________ 
 1r49(A) : EDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENIPAKILSYNRANRAVAILCNHQ----------mMNLQTKIDAKKEQLADARRDLKSAKADAKVMKDAKT 
         :                                                                                                                          
 1k4t(A) : EDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQTKIDAKKEQLADARRDLKSAKADAKVMKDAKT 
           _____________________________________________________________624________________________________________________________ 

           ______________________705____________________________________________________________                                    
 1r49(A) : KKVVESKKKAVQRLEEQLMKLEVQATDREENKQ-----sKLNFLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF                                    
         :                                                                                                                          
 1k4t(A) : KKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKLN-lDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF                                    
           ______________________705____________________________________________________________                                    

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
14.9
Translation
(A)
-1.8
Closure
(%)
56.5
Bending Residues
( green )
  624 - 646
  705 - 706
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Mixed

PyMOL Script

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