Epidermal Growth Factor Receptor

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Epidermal Growth Factor Receptor
  Conformer 1
(PDB) 		1yy9 (A)
  Conformer 2
(PDB) 		2ahx (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 273 2.36   6 - 240   259 - 303
2 119 1.67   241 - 258   483 - 485   496 - 497   505 - 510   512 - 512   514 - 525   532 - 609
3 201 1.74   306 - 482   486 - 495   498 - 504   511 - 511   513 - 513   526 - 531

Sequence


           ________________________________________________________________________________________________________________________ 
 1yy9(A) : EEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNY--DANKTGLKELPMRNLQEI 
         :                                                                                                                          
 2ahx(A) : **QSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGN-FGLQELGLKNLTEI 
           ________________________________________________________________________________________________________________________ 

           ______________________________________________________________________________________________________________________24 
 1yy9(A) : LHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDT 
         :                                                                                                                          
 2ahx(A) : LNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTL---VSTg-CGRCHKSC-TGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQ 
           ______________________________________________________________________________________________________________________23 

           0_______________258__________________________________________303________________________________________________________ 
 1yy9(A) : CPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTH 
         :                                                                                                                          
 2ahx(A) : CPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVV-DSSSCVRACPSSKMEVEENGIKMCKPCT-iCPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNA 
           7_______________255__________________________________________299________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 1yy9(A) : TPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENKCKATG 
         :                                                                                                                          
 2ahx(A) : IEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEG 
           ________________________________________________________________________________________________________________________ 

           482__________495______504___510____________525___531____________________________________________________________________ 
 1yy9(A) : QVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCKLLEGEPREFVENSECIQCHPECLPQAMNI-TCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHP 
         :                                                                                                                          
 2ahx(A) : MVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENDSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGAN-SFIFKYADPDRECHPCHP 
           478__________491______500___506____________521___527____________________________________________________________________ 

           ______________________                                                                                                   
 1yy9(A) : NCTYGCTGPGLRGCPT******                                                                                                   
         :                                                                                                                          
 2ahx(A) : NCTQGCNGPTSHDCIYYPWTGH                                                                                                   
           ______________________                                                                                                   

Morph
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Domain Pairs

Fixed Domain Moving Domain Rotation Angle Translation   (A) Closure Bending Residues  
1 2 28.0 1.3 18.4   240 - 241   258 - 259 Bending Region Analysis
1 3 26.8 4.7 94.1   303 - 306 Bending Region Analysis
3 2 19.7 -0.1 63.4   482 - 483   485 - 486   495 - 498   504 - 505   510 - 514   525 - 526   531 - 532 Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification:

No Contacts

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification:

No Contacts

Conformer 1 Contact:
Residue 3 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 3

Movement classification:

No Contacts

PyMOL Script

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