Epidermal Growth Factor Receptor

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Epidermal Growth Factor Receptor
  Conformer 1
(PDB) 		1nql (A)
  Conformer 2
(PDB) 		2ahx (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 244 1.96   6 - 242   257 - 269
2 139 1.41   243 - 256   483 - 491   496 - 612
3 31 1.55   274 - 305
4 180 1.72   306 - 482   492 - 495

Sequence


           ________________________________________________________________________________________________________________________ 
 1nql(A) : EKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNY--DANKTGLKELPMRNLQEIL 
         :                                                                                                                          
 2ahx(A) : *QSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGN-FGLQELGLKNLTEIL 
           ________________________________________________________________________________________________________________________ 

           _______________________________________________________________________________________________________________________2 
 1nql(A) : HGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTC 
         :                                                                                                                          
 2ahx(A) : NGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTL---VSTg-CGRCHKSC-TGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQC 
           _______________________________________________________________________________________________________________________2 

           42________253_____________269_________________________________305_______________________________________________________ 
 1nql(A) : PPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHT 
         :                                                                                                                          
 2ahx(A) : PQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVV-DSSSCVRACPSSKMEVEENGIKMCKPCT-iCPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAI 
           39________250_____________266_________________________________301_______________________________________________________ 

           _______________________________________________________________________________________________________________________4 
 1nql(A) : PPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQ 
         :                                                                                                                          
 2ahx(A) : EAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGM 
           _______________________________________________________________________________________________________________________4 

           82_____490__495_________________________________________________________________________________________________________ 
 1nql(A) : VCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCKLLEGEPREFVENSECIQCHPECLPQAMNI-TCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPN 
         :                                                                                                                          
 2ahx(A) : VCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENDSICVECDPQCEKMEDGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGAN-SFIFKYADPDRECHPCHPN 
           78_____486__491_________________________________________________________________________________________________________ 

           _____________________                                                                                                    
 1nql(A) : CTYGCTGPGLEGCPT******                                                                                                    
         :                                                                                                                          
 2ahx(A) : CTQGCNGPTSHDCIYYPWTGH                                                                                                    
           _____________________                                                                                                    

Morph
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Domain Pairs

Fixed Domain Moving Domain Rotation Angle Translation   (A) Closure Bending Residues  
1 2 33.7 -3.7 94.5   242 - 244   253 - 257 Bending Region Analysis
1 3 38.2 -1.4 89.7   269 - 274 Bending Region Analysis
4 3 18.8 -1.0 93.0   305 - 308 Bending Region Analysis
4 2 17.1 -0.2 71.5   482 - 483   490 - 492   495 - 496 Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification:

No Contacts

Conformer 1 Contact:
Residue 4 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 4

Movement classification: Hinge

Conformer 1 Contact:
Residue 4 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 4

Movement classification: Hinge

PyMOL Script

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