Monoclonal Antibody 2D12.5, Lambda Light Chain

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Monoclonal Antibody 2D12.5, Lambda Light Chain
  Conformer 1
(PDB) 		1yuh (A)
  Conformer 2
(PDB) 		1sm3 (L)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 125 0.92   4 - 114   138 - 149   175 - 176
2 81 0.97   115 - 137   150 - 174   177 - 209

Sequence


           ______________________________________________________________________________________________________________114_______ 
 1yuh(A) : AVVTQESALTTSPGETVTLTCRSSTGAVTTSNYANWVQEKPDRLFTGLIGGTNNRGPGVPARFSGSLIGDKAALTITGAQTEDEAIYFCALWYSNHWVFGGGTKLTVLgQPKSSPSVTLF 
         :                                                                                                                          
 1sm3(L) : IVVTQESALTTSPGETVTLTCRSSTGAVTTSNYANWVQEKPDHLFTGLIGGTNNRAPGVPARFSGSLIGDKAALTITGAQTEDEAIYFCALWYSNHWVFGGGTKLTVLGSEKSSPSVTLF 
           ______________________________________________________________________________________________________________111_______ 

           _____________137_________149______________________174______________________________________                              
 1yuh(A) : PPSSEELETNKATLVCTITDFYPGVVTVDWKVDGTPVTEGMETTQPSKQSNNKYMASSYLTLSARAWERHASYSCQVTHEGHTVEKSLSRA                              
         :                                                                                                                          
 1sm3(L) : PPSSEELETNKATLVCTITDFYPGVVTVDWKVDGTPVTQGMETTQPSKQSNNKYMASSYLTLTARAWERHSSYSCQVTHEGHTVEKSLSR*                              
           _____________134_________146______________________171______________________________________                              

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		12.3
Translation
(A) 		0.0
Closure
(%) 		3.9
Bending Residues
( green ) 		  114 - 115
  137 - 139
  149 - 150
  174 - 177
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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