Glucokinase Isoform 2

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Glucokinase Isoform 2
  Conformer 1
(PDB)
1v4s (A)
  Conformer 2
(PDB)
1v4t (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 306 2.91   17 - 62   99 - 102   204 - 459
2 104 6.1   73 - 98   103 - 203

Sequence


           _______________________________________________62_____________________________93________________________________________ 
 1v4s(A) : TLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDF 
         :                                                                                                                          
 1v4t(A) : *MVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDF 
           _______________________________________________62_____________________________93________________________________________ 

           ______________________________________________________________198_______________________________________________________ 
 1v4s(A) : LDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCV 
         :                                                                                                                          
 1v4t(A) : LDKHQMKHKKLPLGFTFSFPVRH-----------------------nVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCV 
           ______________________________________________________________198_______________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 1v4s(A) : NTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACES 
         :                                                                                                                          
 1v4t(A) : NTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACES 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________                                 
 1v4s(A) : VSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKAC                                 
         :                                                                                                                          
 1v4t(A) : VSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKAC                                 
           ________________________________________________________________________________________                                 

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
104.4
Translation
(A)
-0.4
Closure
(%)
93.6
Bending Residues
( green )
  62 - 73
  93 - 103
  198 - 204
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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