Immunoglobulin G1 (Igg1)

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Immunoglobulin G1 (Igg1)
  Conformer 1
(PDB) 		1mco (H)
  Conformer 2
(PDB) 		1igt (B)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 105 1.29   222 - 326
2 99 7.29   119 - 218
3 100 1.1   327 - 426
4 111 1.58   3 - 115

Sequence


           __________________________________________________________________________________________________________________114___ 
 1mco(H) : PLVLQESGPGLVKPSEALSLTCTVSGDSINTILYYWSWIRQPPGKGLEWIGYIYYSG-STYGNPSLKSRVTISVNTSKNQFYSKLSSVTAADTAVYYCARVP--LVVNPWGQGTLVTVSS 
         :                                                                                                                          
 1igt(B) : EVKLQESGGGLVQPGGSLKLSCATSGFTFSD--YYMYWVRQTPEKRLEWVAYISNGGGSTYYPDTVKGRFTISRDNAKNTLYLQMSRLKSEDTAMYYCARHGGYYAMDYWGQGTTVTVSS 
           __________________________________________________________________________________________________________________110___ 

           ______________________________________________________________________________________________214_______________________ 
 1mco(H) : ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPQPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRV----------------APELLG 
         :                                                                                                                          
 1igt(B) : AKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSD-LYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGPTIKPCPPCKCPAPNLLG 
           ______________________________________________________________________________________________222_______________________ 

           ______________________________________________________________________________________________________326_______________ 
 1mco(H) : GPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPQVKFNWYVDGVQVHNAKTKPREQQYNSTYRVVSVLTVLHQNWLDGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRE 
         :                                                                                                                          
 1igt(B) : GPSVFIFPPKIKDVLMISLSPIVTCVVVDVSEDDPDVQISWFVNNVEVHTAQTQTHREDYNSTLRVVSALPIQHQDWMSGKEFKCKVNNKDLPAPIERTISKPKGSVRAPQVYVLPPPEE 
           ______________________________________________________________________________________________________361_______________ 

           _______________________________________________________________________________________                                  
 1mco(H) : EMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSL                                  
         :                                                                                                                          
 1igt(B) : EMTKKQVTLTCMVTDFMPEDIYVEWTNNGKTELNYKNTEPVLDSDGSYFMYSKLRVEKKNWVERNSYSCSVVHEGLHNHHTTKSFSR                                  
           _______________________________________________________________________________________                                  

Morph
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Domain Pairs

Fixed Domain Moving Domain Rotation Angle Translation   (A) Closure Bending Residues  
1 2 175.0 31.9 59.8   214 - 223 Bending Region Analysis
1 3 25.7 2.2 74.2   326 - 329 Bending Region Analysis
4 2 51.2 8.0 87.8   114 - 119 Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification:

No Contacts

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 4 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 4

Movement classification: Hinge

PyMOL Script

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