Importin Alpha Subunit

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Importin Alpha Subunit
  Conformer 1
(PDB)
1wa5 (B)
  Conformer 2
(PDB)
1bk5 (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 77 0.41   174 - 175   182 - 182   194 - 244   250 - 260   271 - 282
2 87 0.75   98 - 173   176 - 181   189 - 193
3 237 0.78   245 - 249   261 - 266   283 - 508

Sequence


           ________________________________________________________________________________________________________________________ 
 1wa5(B) : fVPEYRRTeLRRRRDTQQVELRKAKRDEALAKRRNFqELPQMTQQLNSDDMQEQLSATVKFRQILSREHRPPIDVVIQAGVVPRLVEFMRENQPEMLQLEAAWALTNIASGTSAQTKVVV 
         :                                                                                                                          
 1bk5(A) : **************************************LPQMTQQLNSDDMQEQLSATVKFRQILSREHRPPIDVVIQAGVVPRLVEFMRENQPEMLQLEAAWALTNIASGTSAQTKVVV 
           ________________________________________________________________________________________________________________________ 

           173_____181_______191__________________________________________________244_248_________260___266_____________282________ 
 1wa5(B) : DADAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSNKPSLIRTATWTLSNLCRGKKPQPDWSVVSQALPTLAKLIYSMDTETLVDACWAISYLSDGPQE 
         :                                                                                                                          
 1bk5(A) : DADAVPLFIQLLYTGSVEVKEQAIWALGNVAGDSTDYRDYVLQCNAMEPILGLFNSNKPSLIRTATWTLSNLCRGKKPQPDWSVVSQALPTLAKLIYSMDTETLVDACWAISYLSDGPQE 
           173_____181_______191__________________________________________________244_248_________260___266_____________282________ 

           ________________________________________________________________________________________________________________________ 
 1wa5(B) : AIQAVIDVRIPKRLVELLSHESTLVQTPALRAVGNIVTGNDLQTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPPLVKLLEVAEYKTKKEACWAISNA 
         :                                                                                                                          
 1bk5(A) : AIQAVIDVRIPKRLVELLSHESTLVQTPALRAVGNIVTGNDLQTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIPPLVKLLEVAEYKTKKEACWAISNA 
           ________________________________________________________________________________________________________________________ 

           _______________________________________________________________________________________________________                  
 1wa5(B) : SSGGLQRPDIIRYLVSQGCIKPLCDLLEIADNRIIEVTLDALENILKMGEADKEARGLNINENADFIEKAGGMEKIFNCQQNENDKIYEKAYKIIETYFGEEE                  
         :                                                                                                                          
 1bk5(A) : SSGGLQRPDIIRYLVSQGCIKPLCDLLEIADNRIIEVTLDALENILKMGEADKEARGLNINENADFIEKAGGMEKIFNCQQNENDKIYEKAYKIIETYFG***                  
           _______________________________________________________________________________________________________                  

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
9.3
Translation
(A)
0.2
Closure
(%)
63.1
Bending Residues
( green )
  173 - 176
  181 - 189
  191 - 194
Bending Region Analysis
Property Value
Fixed Domain
( blue )
1
Moving Domain
( yellow )
3
Rotation Angle
(deg)
8.0
Translation
(A)
0.2
Closure
(%)
87.8
Bending Residues
( green )
  244 - 245
  248 - 250
  260 - 261
  266 - 271
  282 - 283
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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