DynDom - Protein Domain Motions

Insulin Receptor Tyrosine Kinase Domain

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Insulin Receptor Tyrosine Kinase Domain
Conformer 1 (PDB)	1irk (A)
Conformer 2 (PDB)	1p14 (B)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	155	1.47	328 - 482
2	277	2.0	33 - 325
3	336	7.22	483 - 672 730 - 926

Sequence

`________________________________________________________________________________________________________________________` `6jk8(A) : EICGPGIDIRNDYQQLKRLENCTVIEGYLHILLIS--rSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLS` `:` `6jk8(B) : EICGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKArSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADLCYLS` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `6jk8(A) : TVDWSLILDAVSNNYIVGNKPPKECGDLCP-cEKTTINNEYNYRCWTTNRCQKMCPSTC---aCTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRD` `:` `6jk8(B) : TVDWSLILDAVSNNYIVGNKPPKECGDLCPGcEKTTINNEYNYRCWTTNRCQKMCPSTCGKRACTENNECCHPECLGSCSAPDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRD` `________________________________________________________________________________________________________________________` `_______________________________________322______________________________________________________________________________` `6jk8(A) : FCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLS` `:` `6jk8(B) : FCANILSAESSDSEGFVIHDGECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLS` `_______________________________________322______________________________________________________________________________` `____________________________________________________________________________479_________________________________________` `6jk8(A) : FLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDL` `:` `6jk8(B) : FLKNLRLILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTSKNRIIITWHRYRPPDYRDL` `____________________________________________________________________________479_________________________________________` `________________________________________________________________________________________________________________________` `6jk8(A) : ISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGN` `:` `6jk8(B) : ISFTVYYKEAPFKNVTEY--------nSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGN` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `6jk8(A) : LSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRKYAgPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPyPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFV` `:` `6jk8(B) : LSYYIVRWQRQPQDGYLYRHNYCSKDKIPIRK-------------eKQAEKEEAEYRKVFENFLHNSI----eYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFV` `________________________________________________________________________________________________________________________` `_____________________________________________________________________________________________________________` `6jk8(A) : FARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAKTGY` `:` `6jk8(B) : FARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVQAK***` `_____________________________________________________________________________________________________________`

Morph

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Status: Initialising

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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	55.8
Translation (A)	3.5
Closure (%)	39.6
Bending Residues ( green )	322 - 330
Bending Region Analysis

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( yellow )	3
Rotation Angle (deg)	99.6
Translation (A)	-1.0
Closure (%)	91.8
Bending Residues ( green )	479 - 489
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

UDP-N-ACETYLMURAMOYL-L-ALANINE

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