3-Isopropylmalate Dehydrogenase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name 3-Isopropylmalate Dehydrogenase
  Conformer 1
(PDB)
1osj (A)
  Conformer 2
(PDB)
1dr0 (B)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 184 0.57   3 - 92   96 - 99   251 - 260   263 - 342
2 156 0.34   93 - 95   100 - 250   261 - 262

Sequence


           __________________________________________________________________________________________92_95__99_____________________ 
 1osj(A) : MKVAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGAAIDAFGEPFPEPTRKGVEEAEAVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLSPLKE 
         :                                                                                                                          
 1dr0(B) : MKVAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGAAIDAFGEPFPEPTRKGVEEAEAVLLGSVGGPKWDGLPRKIRPETGLLSLRKSQDLFANLRPAKVFPGLERLSPLKE 
           __________________________________________________________________________________________92_95__99_____________________ 

           ________________________________________________________________________________________________________________________ 
 1osj(A) : EIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERYSKPEVERVARVAFELARKRRKHVVSVDKANVLEVGEFWRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFG 
         :                                                                                                                          
 1dr0(B) : EIARGVDVLIVRELTGGIYFGEPRGMSEAEAWNTERYSKPEVERVARVAFELARKRRKHVVSVDKANVLEVGEFWRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFDVVVTGNIFG 
           ________________________________________________________________________________________________________________________ 

           ____247__________260______________________________________________________________________________________               
 1osj(A) : DILSDLASVLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGLVELARKVEDAVAKALLETPPPDLGGSAGTEAFTATVLRHLA*               
         :                                                                                                                          
 1dr0(B) : DILSDLASVLPGSLGLLPSASLGRGTPVFEPVHGSAPDIAGKGIANPTAAILSAAMMLEHAFGLVELARKVEDAVAKALLETPPPDLGGSAGTEAFTATVTATVGI               
           ____247__________260______________________________________________________________________________________               

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
5.9
Translation
(A)
-0.2
Closure
(%)
15.7
Bending Residues
( green )
  92 - 93
  95 - 96
  99 - 100
  247 - 258
  260 - 263
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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