Metabotropic Glutamate Receptor Subtype 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Metabotropic Glutamate Receptor Subtype 1
  Conformer 1
(PDB)
1ewk (B)
  Conformer 2
(PDB)
1ewv (B)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 287 0.68   38 - 209   233 - 236   318 - 319   342 - 478   500 - 500
2 151 0.53   210 - 232   237 - 317   320 - 341   479 - 499   501 - 504

Sequence


           ________________________________________________________________________________________________________________________ 
 1ewk(B) : QRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRkPIAGVIGPGSSSVAIQVQNLLQLFDIPQI 
         :                                                                                                                          
 1ewv(B) : *RSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRkPIAGVIGPGSSSVAIQVQNLLQLFDIPQI 
           ________________________________________________________________________________________________________________________ 

           _______________________209____________________232_______________________________________________________________________ 
 1ewk(B) : AYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAM 
         :                                                                                                                          
 1ewv(B) : AYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAM 
           _______________________209____________________232_______________________________________________________________________ 

           ___________317_____________________341__________________________________________________________________________________ 
 1ewk(B) : RRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEENYVQDSKMGFVINAIYAMAHG 
         :                                                                                                                          
 1ewv(B) : RRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEENYVQDSKMGFVINAIYAMAHG 
           ___________317_____________________341__________________________________________________________________________________ 

           ____________________________________________________478__________________499_____________                                
 1ewk(B) : LQNMHHALCPGHVGLCDAMKPIDGRKLLDFLIKSSFVGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKI                                
         :                                                                                                                          
 1ewv(B) : LQNMHHALCPGHVGLCDAMKPIDGRKLLDFLIKSSFVGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKI                                
           ____________________________________________________478__________________499_____________                                

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
9.4
Translation
(A)
0.1
Closure
(%)
44.4
Bending Residues
( green )
  209 - 213
  232 - 233
  235 - 240
  317 - 320
  341 - 346
  478 - 479
  499 - 501
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Mixed

PyMOL Script

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