Mitogen-Activated Protein Kinase 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Mitogen-Activated Protein Kinase 1
  Conformer 1
(PDB) 		2fys (A)
  Conformer 2
(PDB) 		2ojg (A)
  Window Length 13
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 303 1.76   23 - 169   191 - 349
2 21 4.63   170 - 190

Sequence


           ________________________________________________________________________________________________________________________ 
 2fys(A) : GPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNLNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYF 
         :                                                                                                                          
 2ojg(A) : *********FDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYF 
           ________________________________________________________________________________________________________________________ 

           _______________________________________169__________________190_________________________________________________________ 
 2fys(A) : LYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNS-gYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 
         :                                                                                                                          
 2ojg(A) : LYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 
           _______________________________________169__________________190_________________________________________________________ 

           _____________________________________________________________________________________________________________            
 2fys(A) : EDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGY            
         :                                                                                                                          
 2ojg(A) : EDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKF--eLDDLPKEKLKELIFEETARFQPG*            
           _____________________________________________________________________________________________________________            

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		48.1
Translation
(A) 		0.0
Closure
(%) 		95.2
Bending Residues
( green ) 		  169 - 170
  190 - 206
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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