Nad-Dependent Deacetylase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Nad-Dependent Deacetylase
  Conformer 1
(PDB) 		2h2i (A)
  Conformer 2
(PDB) 		2h59 (B)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 146 0.64   3 - 30   74 - 116   167 - 194   196 - 242
2 94 1.78   31 - 73   117 - 166   195 - 195

Sequence


           ____________________________30_________________________________________73________________________________________116____ 
 2h2i(A) : MKMKEFLDLLNESRLTVTLTGAGISTPSGIPDFRGPNGIYKKYSQNVFDIDFFYSHPEEFYRFAKEGIFPMLQAKPNLAHVLLAKLEEKGLIEAVITQNIDRLHQRAGSKKVIELHGNVE 
         :                                                                                                                          
 2h59(B) : MKMKEFLDLLNESRLTVTLTGAGISTPSGIPDFRGPNGIYKKYSQNVFDIDFFYSHPEEFYRFAKEGIFPMLQAKPNLAHVLLAKLEEKGLIEAVITQNIDRLHQRAGSKKVIELAGNVE 
           ____________________________30_________________________________________73________________________________________116____ 

           ___________________________________________166______________________191_________________________________________________ 
 2h2i(A) : EYYCVRCEKKYTVEDVIKKLESSDVPLCDDCNSLIRPNIVFFGENLPQDALREAIGLSSRASLMIVLGSSLVVYPAAELPLITVRSGGKLVIVNLGETPFDDIATLKYNMDVVEFARRVM 
         :                                                                                                                          
 2h59(B) : EYYCVRCEKKYTVEDVIKKLESSDVPLCDDCNSLIRPNIVFFGENLPQDALREAIGLSSRASLMIVLGSSLVVYPAAELPLITVRSGGKLVIVNLGETPFDDIATLKYNMDVVEFARRVM 
           ___________________________________________166______________________191_________________________________________________ 

           ______                                                                                                                   
 2h2i(A) : EEGG**                                                                                                                   
         :                                                                                                                          
 2h59(B) : EEGGIS                                                                                                                   
           ______                                                                                                                   

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		19.8
Translation
(A) 		-0.5
Closure
(%) 		99.2
Bending Residues
( green ) 		  30 - 31
  73 - 74
  116 - 117
  166 - 168
  191 - 199
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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