Peroxisome Proliferator-Activated Receptor Gamma

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Peroxisome Proliferator-Activated Receptor Gamma
  Conformer 1
(PDB) 		2hfp (A)
  Conformer 2
(PDB) 		4prg (D)
  Window Length 7
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 239 2.2   210 - 448
2 25 3.66   449 - 473

Sequence


           ________________________________________________________________________________________________________________________ 
 2hfp(A) : PESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEI 
         :                                                                                                                          
 4prg(D) : *ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEI 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 2hfp(A) : IYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQI 
         :                                                                                                                          
 4prg(D) : IYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQI 
           ________________________________________________________________________________________________________________________ 

           448_____________________________                                                                                         
 2hfp(A) : VTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY                                                                                         
         :                                                                                                                          
 4prg(D) : VTEHVQLLQVIKKTETDMSLHPLLQEIYKDL*                                                                                         
           448_____________________________                                                                                         

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		26.5
Translation
(A) 		-2.5
Closure
(%) 		92.7
Bending Residues
( green ) 		  448 - 449
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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