Proto-Oncogene Tyrosine-Protein Kinase Abl1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Proto-Oncogene Tyrosine-Protein Kinase Abl1
  Conformer 1
(PDB) 		1opj (A)
  Conformer 2
(PDB) 		2g1t (D)
  Window Length 13
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 245 2.3   251 - 398   419 - 515
2 20 4.63   399 - 418

Sequence


           ________________________________________________________________________________________________________________________ 
 1opj(A) : AMDPSSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYM 
         :                                                                                                                          
 2g1t(D) : **GHMSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYM 
           ________________________________________________________________________________________________________________________ 

           _______________________________396___________________418________________________________________________________________ 
 1opj(A) : ATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEG 
         :                                                                                                                          
 2g1t(D) : ATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEG 
           _______________________________377___________________399________________________________________________________________ 

           _______________________________________________                                                                          
 1opj(A) : CPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKEL                                                                          
         :                                                                                                                          
 2g1t(D) : CPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSI********                                                                          
           _______________________________________________                                                                          

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		107.0
Translation
(A) 		-1.2
Closure
(%) 		33.2
Bending Residues
( green ) 		  396 - 399
  418 - 419
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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