Proto-Oncogene Tyrosine-Protein Kinase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Proto-Oncogene Tyrosine-Protein Kinase
  Conformer 1
(PDB)
3lck  
  Conformer 2
(PDB)
2ofv (B)
  Window Length 7
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 179 2.54   286 - 306   320 - 496
2 56 0.67   238 - 285   307 - 319

Sequence


           ____________________________________________277__________________________306__________319_______________________________ 
 3lck    : KPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAE 
         :                                                                                                                          
 2ofv(B) : *PWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQG-----aFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAE 
           ____________________________________________277__________________________306__________319_______________________________ 

           ________________________________________________________________________________________________________________________ 
 3lck    : GMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEtAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQ 
         :                                                                                                                          
 2ofv(B) : GMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIED----------pIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYP-------iQNLE-gYRMVRPDNCPEELYQ 
           ________________________________________________________________________________________________________________________ 

           ______________________________                                                                                           
 3lck    : LMRLCWKERPEDRPTFDYLRSVLEDFFTAT                                                                                           
         :                                                                                                                          
 2ofv(B) : LMRLCWKERPEDRPTFDYLRSVLEDFFT**                                                                                           
           ______________________________                                                                                           

Morph

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Status: Initialising

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
19.0
Translation
(A)
0.8
Closure
(%)
45.5
Bending Residues
( green )
  277 - 286
  306 - 308
  319 - 320
Bending Region Analysis

Dynamic Contact Graph

The dynamic contact graph is still being generated. Progress: Initialising

PyMOL Script

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