DynDom - Protein Domain Motions

Son Of Sevenless Protein Homolog 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Son Of Sevenless Protein Homolog 1
Conformer 1 (PDB)	1xdv (B)
Conformer 2 (PDB)	1xdv (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	115	0.0	421 - 547
2	202	0.45	202 - 402 549 - 549
3	148	0.96	568 - 758
4	284	0.0	759 - 1042

Sequence

`________________________________________________________________________________________________________________________` `1xdv(B) : TYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSANDVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYARDILRPGFHDRFLSQLSKPG` `:` `1xdv(A) : TYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSANDVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYARDILRPGFHDRFLSQLSKPG` `________________________________________________________________________________________________________________________` `________________________________________________________________________________402_____________________________________` `1xdv(B) : AALYLQSIGEGFKEAVQYVLPRLLLAPVYHCLHYFELLKQLEEKSEDQEDKECLKQAITALLNVQSGMEKICSKSLAKRRLSESAiKKMNEIQKNIDGWEGKDIGQCCNEFIMEGTLTRV` `:` `1xdv(A) : AALYLQSIGEGFKEAVQYVLPRLLLAPVYHCLHYFELLKQLEEKSEDQEDKECLKQAITALLNVQSGMEKICSKSLAKRRLSESAiKKMNEIQKNIDGWEGKDIGQCCNEFIMEGTLTRV` `________________________________________________________________________________402_____________________________________` `_______________________________________________________________________________547______________________________________` `1xdv(B) : GAKHERHIFLFDGLMICCKSNeYRLKEKFFMRKVQINDKDDTNEYKHAFEIILKDENSVIFSAKSAEEKNNWMAALISLQYRSTLrLPSADVYRFAEPDSEENIIFEEgIPIIKAGTVIK` `:` `1xdv(A) : GAKHERHIFLFDGLMICCKSNeYRLKEKFFMRKVQINDKDDTNEYKHAFEIILKDENSVIFSAKSAEEKNNWMAALISLQYRST-rLPSADVYRFAEPDSEENIIFEEgIPIIKAGTVIK` `_______________________________________________________________________________547______________________________________` `___________________________________________________________________________________________________________740__________` `1xdv(B) : LIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPrFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKsPPTVEWHI` `:` `1xdv(A) : LIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPrFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKsPPTVEWHI` `___________________________________________________________________________________________________________740__________` `________________________________________________________________________________________________________________________` `1xdv(B) : SRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYR` `:` `1xdv(A) : SRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYR` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1xdv(B) : LDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEF` `:` `1xdv(A) : LDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEF` `________________________________________________________________________________________________________________________` `_______________________________________` `1xdv(B) : TDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSN` `:` `1xdv(A) : TDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSN` `_______________________________________`

Morph

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Domain Pairs

Fixed Domain	Moving Domain	Rotation Angle	Translation (A)	Closure	Bending Residues
1	2	10.3	-1.2	42.2	402 - 421 547 - 549	Bending Region Analysis
1	3	21.8	2.2	13.6	547 - 569	Bending Region Analysis
4	3	39.8	5.3	80.7	740 - 759	Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification:

No Contacts

Conformer 1 Contact:
Residue 4 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 4

Movement classification: Hinge

PyMOL Script

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