DynDom - Protein Domain Motions

Son Of Sevenless Protein Homolog 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Son Of Sevenless Protein Homolog 1
Conformer 1 (PDB)	1xdv (A)
Conformer 2 (PDB)	1xd4 (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	145	1.37	547 - 727 730 - 739
2	321	0.44	202 - 546 728 - 729
3	288	1.07	740 - 1042

Sequence

`________________________________________________________________________________________________________________________` `1xdv(A) : TYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSANDVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYARDILRPGFHDRFLSQLSK` `:` `1xd4(A) : EQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSANDVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYARDILRPGFHDRFLSQLSK` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1xdv(A) : PGAALYLQSIGEGFKEAVQYVLPRLLLAPVYHCLHYFELLKQLEEKSEDQEDKECLKQAITALLNVQSGMEKICSKSLAKRRLSESA-iKKMNEIQKNIDGWEGKDIGQCCNEFIMEGTL` `:` `1xd4(A) : PGAALYLQSIGEGFKEAVQYVLPRLLLAPVYHCLHYFELLKQLEEKSEDQEDKECLKQAITALLNVQSGMEKICSKSLAKRRLSESAaIKKMNEIQKNIDGWEGKDIGQCCNEFIMEGTL` `________________________________________________________________________________________________________________________` `_________________________________________________________________________________________542____________________________` `1xdv(A) : TRVGAKHERHIFLFDGLMICCKSN------------eYRLKEKFFMRKVQINDKDDTNEYKHAFEIILKDENSVIFSAKSAEEKNNWMAALISLQYRST------------------rLP` `:` `1xd4(A) : TRVGAKHERHIFLFDGLMICCKSNHGQPRLPGASNAEYRLKEKFFMRKVQINDKDDTNEYKHAFEIILKDENSVIFSAKSAEEKNNWMAALISLQYRSTLERMLDVTMLQEEKEEQMRLP` `_________________________________________________________________________________________542____________________________` `________________________________________________________________________________________________________________________` `1xdv(A) : SADVYRFAEPDSEENIIFEEgIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEP----------------------rFRKEYIQPVQLRVLNVCRHW` `:` `1xd4(A) : SADVYRFAEPDSEENIIFEEgIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHW` `________________________________________________________________________________________________________________________` `_______________________722______________739_____________________________________________________________________________` `1xdv(A) : VEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKK---------sPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLL` `:` `1xd4(A) : VEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIAhNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLL` `_______________________722______________739_____________________________________________________________________________` `________________________________________________________________________________________________________________________` `1xdv(A) : KMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEE` `:` `1xd4(A) : KMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEE` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________` `1xdv(A) : GNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSN` `:` `1xd4(A) : GNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPR` `________________________________________________________________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	10.0
Translation (A)	-0.3
Closure (%)	25.2
Bending Residues ( green )	542 - 547 722 - 730
Bending Region Analysis

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( yellow )	3
Rotation Angle (deg)	15.1
Translation (A)	-2.3
Closure (%)	95.5
Bending Residues ( green )	739 - 759
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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