Thymidylate Synthase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Thymidylate Synthase
  Conformer 1
(PDB) 		1b02 (A)
  Conformer 2
(PDB) 		1bkp (B)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 237 0.66   5 - 20   42 - 182   186 - 189   193 - 222   229 - 274
2 36 0.97   21 - 41   183 - 185   190 - 192   223 - 228   275 - 277

Sequence


           __________________20___________________41_______________________________________________________________________________ 
 1b02(A) : MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVISKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDGTIGHAYGFQLGKKNRSLN 
         :                                                                                                                          
 1bkp(B) : *TQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVISKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDGTIGHAYGFQLGKKNRSLN 
           __________________20___________________41_______________________________________________________________________________ 

           ___________________________________________________________182_______192___________________________222___228____________ 
 1b02(A) : GEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTPCVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNIGDCHVYTRHIDNLKIQMEREQF 
         :                                                                                                                          
 1bkp(B) : GEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTPCVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNIGDCHVYTRHIDNLKIQMEREQF 
           ___________________________________________________________182_______192___________________________222___228____________ 

           __________________________269__________                                                                                  
 1b02(A) : EAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFEVAV                                                                                  
         :                                                                                                                          
 1bkp(B) : EAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFEVAV                                                                                  
           __________________________269__________                                                                                  

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		12.4
Translation
(A) 		0.3
Closure
(%) 		59.6
Bending Residues
( green ) 		  20 - 21
  41 - 43
  182 - 183
  185 - 190
  192 - 193
  222 - 223
  228 - 229
  269 - 275
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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