DynDom - Protein Domain Motions

Tricorn Protease Interacting Factor F3

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Tricorn Protease Interacting Factor F3
Conformer 1 (PDB)	1z5h (A)
Conformer 2 (PDB)	1z5h (B)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	98	0.42	453 - 454 476 - 481 486 - 511 516 - 527 533 - 553 557 - 563 570 - 586 591 - 593 739 - 739 767 - 768 770 - 770
2	479	0.58	3 - 452 455 - 475 482 - 485 512 - 515
3	199	0.52	528 - 532 554 - 556 564 - 569 587 - 590 594 - 738 740 - 766 769 - 769 771 - 778

Sequence

`________________________________________________________________________________________________________________________` `1z5h(A) : MEVEKYDLTLDFDIQKRTFNGTETITADAGDIVLDAVGLQINWMKVNGRDTAFTYDGQTVRAPGDSQPQKIEISFAGKVSDSLSGIYYAGRENGMITTHFEATDARRMFPCVDHPAYKAV` `:` `1z5h(B) : MEVEKYDLTLDFDIQKRTFNGTETITADAGDIVLDAVGLQINWMKVNGRDTAFTYDGQTVRAPGDSQPQKIEISFAGKVSDSLSGIYYAGRENGMITTHFEATDARRMFPCVDHPAYKAV` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1z5h(A) : FAITVVIDKDYDAISNMPPKRIEVSERKVVEFQDTPRMSTYLLYVGIGKFRYEYEKYRDIDLILASLKDIRSKYPLDMARKSVEFYENYFGIPYALPKMHLISVPEFGAGAMENWGAITF` `:` `1z5h(B) : FAITVVIDKDYDAISNMPPKRIEVSERKVVEFQDTPRMSTYLLYVGIGKFRYEYEKYRDIDLILASLKDIRSKYPLDMARKSVEFYENYFGIPYALPKMHLISVPEFGAGAMENWGAITF` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1z5h(A) : REIYMDIAENSAVTVKRNSANVIAHEIAHQWFGDLVTMKWWNDLWLNESFATFMSYKTMDTLFPEWSFWGDFFVSRTSGALRSDSLKNTHPIEVDVRDPDEISQIFDEISYGKGASILRM` `:` `1z5h(B) : REIYMDIAENSAVTVKRNSANVIAHEIAHQWFGDLVTMKWWNDLWLNESFATFMSYKTMDTLFPEWSFWGDFFVSRTSGALRSDSLKNTHPIEVDVRDPDEISQIFDEISYGKGASILRM` `________________________________________________________________________________________________________________________` `______________________________________________________________________________________449______________________474______` `1z5h(A) : IEDYAGYEEFRKGISKYLNDHKFGNAEGSDLWTAIEDVSGKPVKRVMEYWIKNPGYPVIKLKRNGRKITMYQTRFLLNGEEEGRWPVPVNIKKKDGVERILLEDEASIEADGLIKINADS` `:` `1z5h(B) : IEDYAGYEEFRKGISKYLNDHKFGNAEGSDLWTAIEDVSGKPVKRVMEYWIKNPGYPVIKLKRNGRKITMYQTRFLLNGEEEGRWPVPVNIKKKDGVERILLEDEASIEADGLIKINADS` `______________________________________________________________________________________449______________________474______` `__485_______________________511_515_________527__532__________________553_______563___569______________586_590__________` `1z5h(A) : AGFYRVLYDDATFSDVMGHYRDLSPLDRIGLVDDLFAFLLSGHIDPETYRQRIRNFFDDEDHNVITAIVGQMEYLRMLTHAFDDDARAFCRSRMQFLTGKQDENLKIALGRVSRLYVMVD` `:` `1z5h(B) : AGFYRVLYDDATFSDVMGHYRDLSPLDRIGLVDDLFAFLLSGHIDPETYRQRIRNFFDDEDHNVITAIVGQMEYLRMLTHAFDDDARAFCRSRMQFLTGKQDENLKIALGRVSRLYVMVD` `__485_______________________511_515_________527__532__________________553_______563___569______________586_590__________` `________________________________________________________________________________________________________________________` `1z5h(A) : ESYAEEMSKLFKDFDSAEPEMRSSIATAYALVTGDLKGLLEKFRSVDRDEDRVRIISAFGKLKSNTDLSTVYGMVEKTEIKKQDMISFFSSALETLPGREFIFANLDRIIRLVIRYFTGN` `:` `1z5h(B) : ESYAEEMSKLFKDFDSAEPEMRSSIATAYALVTGDLKGLLEKFRSVDRDEDRVRIISAFGKLKSNTDLSTVYGMVEKTEIKKQDMISFFSSALETLPGREFIFANLDRIIRLVIRYFTGN` `________________________________________________________________________________________________________________________` `_______________738_________________________766______________` `1z5h(A) : RTASRTVEMMIPVIGLDHPDAEDIVRNIGSKNISMGLAKGIEMLAVNRKLVERIRQTAVK` `:` `1z5h(B) : RTASRTVEMMIPVIGLDHPDAEDIVRNIGSKNISMGLAKGIEMLAVNRKLVERIRQTAVK` `_______________738_________________________766______________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	7.2
Translation (A)	0.2
Closure (%)	99.9
Bending Residues ( green )	449 - 455 474 - 482 485 - 486 511 - 512 515 - 516
Bending Region Analysis

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( yellow )	3
Rotation Angle (deg)	5.5
Translation (A)	0.0
Closure (%)	74.3
Bending Residues ( green )	527 - 528 532 - 533 553 - 554 556 - 557 563 - 564 569 - 570 586 - 587 590 - 591 593 - 594 738 - 740 766 - 771
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Shear

PyMOL Script

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