ASPARTYL-TRNA SYNTHETASE
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1eqr(B) : MRTEYCGQLRLSHVGQQVTLCGWVNRRRDLGSLIFIDMRDREGIVQVFFD 
         :                                                    
 1c0a(A) : MRTEYCGQLRLSHVGQQVTLCGWVNRRRDLGSLIFIDMRDREGIVQVFFD 
           __________________________________________________ 

           __________________________________________________ 
 1eqr(B) : PDRADALKLASELRNEFCIQVTGTVRARDEKNINRDMATGEIEVLASSLT 
         :                                                    
 1c0a(A) : PDRADALKLASELRNEFCIQVTGTVRARDEKNINRDMATGEIEVLASSLT 
           __________________________________________________ 

           __________________________________________________ 
 1eqr(B) : IINRADVLPLDSNHVNTEEARLKYRYLDLRRPEMAQRLKTRAKITSLVRR 
         :                                                    
 1c0a(A) : IINRADVLPLDSNHVNTEEARLKYRYLDLRRPEMAQRLKTRAKITSLVRR 
           __________________________________________________ 

           __________________________________________________ 
 1eqr(B) : FMDDHGFLDIETPMLTKATPEGARDYLVPSRVHKGKFYALPQSPQLFKQL 
         :                                                    
 1c0a(A) : FMDDHGFLDIETPMLTKATPEGARDYLVPSRVHKGKFYALPQSPQLFKQL 
           __________________________________________________ 

           __________________________________________________ 
 1eqr(B) : LMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDVETSFMTAPQVREVMEA 
         :                                                    
 1c0a(A) : LMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDVETSFMTAPQVREVMEA 
           __________________________________________________ 

           __________________271_____________________________ 
 1eqr(B) : LVRHLWLEVKGVDLGDFPVMTFAEAERRYGSDKPDLRNPMELTDVADLLK 
         :                                                    
 1c0a(A) : LVRHLWLEVKGVDLGDFPVMTFAEAERRYGSDKPDLRNPMELTDVADLLK 
           __________________271_____________________________ 

           __________________________________________________ 
 1eqr(B) : SVEFAVFAGPANDPKGRVAALRVPGGASLTRKQIDEYGNFVKIYGAKGLA 
         :                                                    
 1c0a(A) : SVEFAVFAGPANDPKGRVAALRVPGGASLTRKQIDEYGNFVKIYGAKGLA 
           __________________________________________________ 

           __________________________________________________ 
 1eqr(B) : YIKVNERAKGLEGINSPVAKFLNAEIIEDILDRTAAQDGDMIFFGADNKK 
         :                                                    
 1c0a(A) : YIKVNERAKGLEGINSPVAKFLNAEIIEDILDRTAAQDGDMIFFGADNKK 
           __________________________________________________ 

           _________________420________431___________________ 
 1eqr(B) : IVADAMGALRLKVGKDLGLTDESKWAPLWVIDFPMFEDDGEGGLTAMHHP 
         :                                                    
 1c0a(A) : IVADAMGALRLKVGKDLGLTDESKWAPLWVIDFPMFEDDGEGGLTAMHHP 
           _________________420________431___________________ 

           ____________________473_477_______________________ 
 1eqr(B) : FTSPKDMTAAELKAAPENAVANAYDMVINGYEVGGGSVRIHNGDMQQTVF 
         :                                                    
 1c0a(A) : FTSPKDMTAAELKAAPENAVANAYDMVINGYEVGGGSVRIHNGDMQQTVF 
           ____________________473_477_______________________ 

           __________________________________________________ 
 1eqr(B) : GILGINEEEQREKFGFLLDALKYGTPPHAGLAFGLDRLTMLLTGTDNIRD 
         :                                                    
 1c0a(A) : GILGINEEEQREKFGFLLDALKYGTPPHAGLAFGLDRLTMLLTGTDNIRD 
           __________________________________________________ 

           ________________________________________           
 1eqr(B) : VIAFPKTTAAACLMTEAPSFANPTALAELSIQVVKKAENN           
         :                                                    
 1c0a(A) : VIAFPKTTAAACLMTEAPSFANPTALAELSIQVVK*****           
           ________________________________________           

Details

  Property   Value
 Conformer 1 1eqr(B)
 Conformer 2 1c0a(A)
 Radius gyration for conformer 1 30.11 A
 Radius gyration for conformer 2 29.84 A
 EC Number 6.1.1.12  
Click here to see the DynDom results or the famliy
 Trigger ligands AMP800
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands No
 Residues in enzyme contacting ligands ALA350  ALA396  GLY348  LEU349  LYS347  PHE304  PRO367  VAL306  VAL368 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT