Chorismate synthase
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1qxo(A) : RYLTAGESHGPRLTAIIEGIPAGLPLTAEDINEDLRRRQGGYGRGGRkIE 
         :                                                    
 1qxo(B) : RYLTAGESHGPRLTAIIEGIPAGLPLTAEDINEDLRRRQGGYGRGGRkIE 
           __________________________________________________ 

           __________________________________________________ 
 1qxo(A) : NDQVVFTSGVRHGKTTGAPITdVINKDHQKWLDIsAEDIEDRLKSKRKIT 
         :                                                    
 1qxo(B) : NDQVVFTSGVRHGKTTGAPITdVINKDHQKWLDIsAEDIEDRLKSKRKIT 
           __________________________________________________ 

           __________________________________________________ 
 1qxo(A) : HPRPGHADLVGGIKYRFDDLRNSLERSSARETTrVAVGAVAKRLLAELDe 
         :                                                    
 1qxo(B) : HPRPGHADLVGGIKYRFDDLRNSLERSSARETTrVAVGAVAKRLLAELDe 
           __________________________________________________ 

           __________________________________________________ 
 1qxo(A) : IANHVVVFGGKEIDVPENLTVAEIKQRAAQSEVSIVNQEREQEIKDYIDQ 
         :                                                    
 1qxo(B) : IANHVVVFGGKEIDVPENLTVAEIKQRAAQSEVSIVNQEREQEIKDYIDQ 
           __________________________________________________ 

           __________________________________________________ 
 1qxo(A) : IKRDGDTIGGVVETVVGGVPVGLGSYVQWDRKLDARLAQAVVSINAFKGV 
         :                                                    
 1qxo(B) : IKRDGDTIGGVVETVVGGVPVGLGSYVQWDRKLDARLAQAVVSINAFKGV 
           __________________________________________________ 

           ________________________________________________30 
 1qxo(A) : EFGLGFEAGYRKGSQVdEILWSKEDGYTRRTNNLGGFEGGtNGQPIVVRG 
         :                                                    
 1qxo(B) : EFGLGFEAGYRKGSQVdEILWSKEDGYTRRTNNLGGFEGGtNGQPIVVRG 
           ________________________________________________30 

           9_________323_________________343_________________ 
 1qxo(A) : VkPIPTLYKPLsVDIETHEPYKATVERSDPTALPAAGveAVVATVLAQEI 
         :                                                    
 1qxo(B) : VkPIPTLYKPLsVDIETHEPYKATVERSDPTALPAAGveAVVATVLAQEI 
           9_________323_________________343_________________ 

           __________________________                         
 1qxo(A) : LEKFSSDNLEELKEAVAKHRDYTKNY                         
         :                                                    
 1qxo(B) : LEKFSSDNLEELKEAVAKHRDYTKNY                         
           __________________________                         

Details

  Property   Value
 Conformer 1 1qxo(A)
 Conformer 2 1qxo(B)
 Radius gyration for conformer 1 23.13 A
 Radius gyration for conformer 2 23.03 A
 EC Number 4.2.3.5  
Click here to see the DynDom results or the famliy
 Trigger ligands EPS5002
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ALA133  ARG134  ARG337  ARG39  ARG45  ARG48  HIS10  HIS110  SER132 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT