3-dehydroquinate synthase
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1xah(A) : MKLQTTYPSNNYPIYVEHGAIKYIGTYLNQFDQSFLLIDEYVNQYFANKF 
         :                                                    
 1xag(A) : MKLQTTYPSNNYPIYVEHGAIKYIGTYLNQFDQSFLLIDEYVNQYFANKF 
           __________________________________________________ 

           __________________________________________________ 
 1xah(A) : D------nVHKVIIPAGEKTKTFEQYQETLEYILSHHVTRNTAIIAVGGG 
         :                                                    
 1xag(A) : DDILSYENVHKVIIPAGEKTKTFEQYQETLEYILSHHVTRNTAIIAVGGG 
           __________________________________________________ 

           __________________________________________________ 
 1xah(A) : ATGDFAGFVAATLLRGVHFIQVPTTILAHDSSVGGKVGINSKQGKNLIGA 
         :                                                    
 1xag(A) : ATGDFAGFVAATLLRGVHFIQVPTTILAHDSSVGGKVGINSKQGKNLIGA 
           __________________________________________________ 

           ____________165___________________________________ 
 1xah(A) : FYRPTAVIYDLDFLKTLPFKQILSGYAEVYKHALLNGESATQDIEQHFKD 
         :                                                    
 1xag(A) : FYRPTAVIYDLDFLKTLPFKQILSGYAEVYKHALLNGESATQDIEQHFKD 
           ____________165___________________________________ 

           _____208__________221_______231___________________ 
 1xah(A) : REILQSLNGMDKYIAKGIETKLDIVVADEKEQGVRKFLNLGHTFGHAVEY 
         :                                                    
 1xag(A) : REILQSLNGMDKYIAKGIETKLDIVVADEKEQGVRKFLNLGHTFGHAVEY 
           _____208__________221_______231___________________ 

           __________________________________________________ 
 1xah(A) : YHKIPHGHAVMVGIIYQFIVANALFDSKHDISHYIQYLIQLGYPLD---- 
         :                                                    
 1xag(A) : YHKIPHGHAVMVGIIYQFIVANALFDSKHDISHYIQYLIQLGYPLDMITD 
           __________________________________________________ 

           __________________________________________________ 
 1xah(A) : -------------------gVQMVLMRQFGDIVVQHVDQLTLQHACEQLK 
         :                                                    
 1xag(A) : LDFETLYQYMLSDKKNDKQGVQMVLMRQFGDIVVQHVDQLTLQHACEQLK 
           __________________________________________________ 

           ___                                                
 1xah(A) : TY*                                                
         :                                                    
 1xag(A) : TYF                                                
           ___                                                

Details

  Property   Value
 Conformer 1 1xah(A)
 Conformer 2 1xag(A)
 Radius gyration for conformer 1 19.98 A
 Radius gyration for conformer 2 19.92 A
 EC Number 4.2.3.4  
Click here to see the DynDom results or the famliy
 Trigger ligands CRB500
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ARG235  ASN146  ASN239  ASP130  GLU178  HIS242  HIS246  HIS256  LEU238  LYS136  LYS181  LYS221  LYS314 
 Residues in extended bending regions contacting ligands ARG235  LYS221 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands ARG235  LYS221 
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT