Ketopantoate reductase
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 1ks9(A) : *MKITVLGCGALGQLWLTALCKQGHEVQGWLRVPQPYCSVNLVETDGSIF 
         :                                                    
 2ofp(B) : SMKITVLGCGALGQLWLTALCKQGHEVQGWLRVPQPYCSVNLVETDGSIF 
           __________________________________________________ 

           __________________________________________________ 
 1ks9(A) : NESLTANDPDFLATSDLLLVTLKAWQVSDAVKSLASTLPVTTPILLIHNG 
         :                                                    
 2ofp(B) : NESLTANDPDFLATSDLLLVTLKAWQVSDAVKSLASTLPVTTPILLIHNG 
           __________________________________________________ 

           __________________________________________________ 
 1ks9(A) : MGTIEELQNIQQPLLMGTTTHAARRDGNVIIHVANGITHIGPARQQDGDY 
         :                                                    
 2ofp(B) : MGTIEELQNIQQPLLMGTTTHAARRDGNVIIHVANGITHIGPARQQDGDY 
           __________________________________________________ 

           ________________168_______________________________ 
 1ks9(A) : SYLADILQTVLPDVAWHNNIRAELWRKLAVNCVINPLTAIWNCPNGELRH 
         :                                                    
 2ofp(B) : SYLADILQTVLPDVAWHNNIRAELWRKLAVNCVINPLTAIWNCPNGELRH 
           ________________168_______________________________ 

           __________________________________________________ 
 1ks9(A) : HPQEIMQICEEVAAVIEREGHHTSAEDLRDYVMQVIDATAENISSMLQDI 
         :                                                    
 2ofp(B) : HPQEIMQICEEVAAVIEREGHHTSAEDLRDYVMQVIDATAENISSMLQDI 
           __________________________________________________ 

           ____________________________________________       
 1ks9(A) : RALRHTEIDYINGFLLRRARAHGIAVPENTRLFEMVKRKESE**       
         :                                                    
 2ofp(B) : RALRHTEIDYINGFLLRRARAHGIAVPENTRLFEMVKRKESEYE       
           ____________________________________________       

Details

  Property   Value
 Conformer 1 1ks9(A)
 Conformer 2 2ofp(B)
 Radius gyration for conformer 1 19.36 A
 Radius gyration for conformer 2 18.57 A
 EC Number 1.1.1.169  
Click here to see the DynDom results or the famliy
 Trigger ligands PAF601
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands Yes
 Residues in enzyme contacting ligands ASN180  ASN184  ASN194  ASN241  ASN98  ILE183  LYS176  SER243  SER244  VAL234 
 Residues in extended bending regions contacting ligands LYS176 
 Residues in extended bending regions making H-bonds or salt-bridges with ligands LYS176 
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT