Pyranose oxidase
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           __________________________________________________ 
 2igk(E) : MDIKYDVVIVGSGPIGCTYARELVGAGYKVAMFDIGEIDSGLKIGAHKKN 
         :                                                    
 2f6c(A) : MDIKYDVVIVGSGPIGCTYARELVGAGYKVAMFDIGEIDSGLKIGAHKKN 
           __________________________________________________ 

           __________________________________________________ 
 2igk(E) : TVEYQKNIDKFVNVIQGQLMSVSVPVNTLVVDTLSPTSWQASTFFVRNGS 
         :                                                    
 2f6c(A) : TVEYQKNIDKFVNVIQGQLMSVSVPVNTLVVDTLSPTSWQASTFFVRNGS 
           __________________________________________________ 

           __________________________________________________ 
 2igk(E) : NPEQDPLRNLSGQAVTRVVGGMSTHWTCATPRFDREQRPLLVKDDADADD 
         :                                                    
 2f6c(A) : NPEQDPLRNLSGQAVTRVVGGMSTHWTCATPRFDREQRPLLVKDDADADD 
           __________________________________________________ 

           __________________________________________________ 
 2igk(E) : AEWDRLYTKAESYFQTGTDQFKESIRHNLVLNKLTEEYKGQRDFQQIPLA 
         :                                                    
 2f6c(A) : AEWDRLYTKAESYFQTGTDQFKESIRHNLVLNKLAEEYKGQRDFQQIPLA 
           __________________________________________________ 

           __________________________________________________ 
 2igk(E) : ATRRSPTFVEWSSANTVFDLQNRPNTDAPEERFNLFPAVACERVVRNALN 
         :                                                    
 2f6c(A) : ATRRSPTFVEWSSANTVFDLQNRPNTDAPEERFNLFPAVACERVVRNALN 
           __________________________________________________ 

           __________________________________________________ 
 2igk(E) : SEIESLHIHDLISGDRFEIKADVYVLTAGAVHNTQLLVNSGFGQLGRPNP 
         :                                                    
 2f6c(A) : SEIESLHIHDLISGDRFEIKADVYVLTAGAVHNTQLLVNSGFGQLGRPNP 
           __________________________________________________ 

           _______________________________376________________ 
 2igk(E) : ANPPELLPSLGSYITEQSLVFCQTVMSTELIDSVKSDMTIRGTPGELTYS 
         :                                                    
 2f6c(A) : TNPPELLPSLGSYITEQSLVFCQTVMSTELIDSVKSDMTIRGTPGELTYS 
           _______________________________376________________ 

           _________________________420______________________ 
 2igk(E) : VTYTPGASTNKHPDWWNEKVKNHMMQHQEDPLPIPFEDPEPQVTTLFQPS 
         :                                                    
 2f6c(A) : VTYTPGASTNKHPDWWNEKVKNHMMQHQEDPLPIPFEDPEPQVTTLFQPS 
           _________________________420______________________ 

           __________________________________________________ 
 2igk(E) : HPWHTQIHRDAFSYGAVQQSIDSRLIVDWRFFGRTEPKEENKLWFSDKIT 
         :                                                    
 2f6c(A) : HPWHTQIHRDAFSYGAVQQSIDSRLIVDWRFFGRTEPKEENKLWFSDKIT 
           __________________________________________________ 

           __________________________________________________ 
 2igk(E) : DAYNMPQPTFDFRFPAGRTSKEAEDMMTDMCVMSAKIGGFLPGSLPQFME 
         :                                                    
 2f6c(A) : DAYNMPQPTFDFRFPAGRTSKEAEDMMTDMCVMSAKIGGFLPGSLPQFMK 
           __________________________________________________ 

           __________________________________________________ 
 2igk(E) : PGLVLHLGGTHRMGFDEKEDNCCVNTDSRVFGFKNLFLGGCGNIPTAYGA 
         :                                                    
 2f6c(A) : PGLVLHLGGTHRMGFDEKEDNCCVNTDSRVFGFKNLFLGGCGNIPTAYGA 
           __________________________________________________ 

           ___________________________                        
 2igk(E) : NPTLTAMSLAIKSCEYIKQNFTPSPFT                        
         :                                                    
 2f6c(A) : NPTLTAMSLAIKSCEYIKQNFTPSPFT                        
           ___________________________                        

Details

  Property   Value
 Conformer 1 2igk(E)
 Conformer 2 2f6c(A)
 Radius gyration for conformer 1 25.88 A
 Radius gyration for conformer 2 25.8 A
 EC Number 1.1.3.10  
Click here to see the DynDom results or the famliy
 Trigger ligands PG41626
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands No
 Residues in enzyme contacting ligands ARG339  ASP147  GLN146  GLU145  PRO144  PRO148 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT