SERYL-tRNA SYNTHETASE
Ligand-induced domain movement details

Jmol view of liganded conformation 2

Domain Movement

domain 1 is binding domain(fixed in space) domain 2 is binding domain(fixed in space)

Sequence


           ________________________________34________________ 
 1ses(A) : MVDLKRLRQEPEVFHRAIREKGVALDLEALLALDREVQELKKRLQEVQTE 
         :                                                    
 1ses(B) : MVDLKRLRQEPEVFHRAIREKGVALDLEALLALDREVQELKKRLQEVQTE 
           ________________________________34________________ 

           ____________________________________88____________ 
 1ses(A) : RNQVAKRVPKAPPEEKEALIARGKALGEEAKRLEEALREKEARLEALLLQ 
         :                                                    
 1ses(B) : RNQVAKRVPKAPPEEKEALIARGKALGEEAKRLEEALREKEARLEALLLQ 
           ____________________________________88____________ 

           __________________________________________________ 
 1ses(A) : VPLPPWPGAPVGGEEANREIKRVGGPPEFSFPPLDHVALMEKNGWWEPRI 
         :                                                    
 1ses(B) : VPLPPWPGAPVGGEEANREIKRVGGPPEFSFPPLDHVALMEKNGWWEPRI 
           __________________________________________________ 

           __________________________________________________ 
 1ses(A) : SQVSGSRSYALKGDLALYELALLRFAMDFMARRGFLPMTLPSYAREKAFL 
         :                                                    
 1ses(B) : SQVSGSRSYALKGDLALYELALLRFAMDFMARRGFLPMTLPSYAREKAFL 
           __________________________________________________ 

           __________________________________________________ 
 1ses(A) : GTGHFPAYRDQVWAIAETDLYLTGTAEVVLNALHSGEILPYEALPLRYAG 
         :                                                    
 1ses(B) : GTGHFPAYRDQVWAIAETDLYLTGTAEVVLNALHSGEILPYEALPLRYAG 
           __________________________________________________ 

           __________________________________________________ 
 1ses(A) : YAPAFRSEAGSFGKDVRGLMRVHQFHKVEQYVLTEASLEASDRAFQELLE 
         :                                                    
 1ses(B) : YAPAFRSEAGSFGKDVRGLMRVHQFHKVEQYVLTEASLEASDRAFQELLE 
           __________________________________________________ 

           __________________________________________________ 
 1ses(A) : NAEEILRLLELPYRLVEVATGDMGPGKWRQVDIEVYLPSEGRYRETHSCS 
         :                                                    
 1ses(B) : NAEEILRLLELPYRLVEVATGDMGPGKWRQVDIEVYLPSEGRYRETHSCS 
           __________________________________________________ 

           __________________________________________________ 
 1ses(A) : ALLDWQARRANLRYRDPEGRVRYAYTLNNTALATPRILAMLLENHQLQDG 
         :                                                    
 1ses(B) : ALLDWQARRANLRYRDPEGRVRYAYTLNNTALATPRILAMLLENHQLQDG 
           __________________________________________________ 

           _____________________                              
 1ses(A) : RVRVPQALIPYMGKEVLEPCG                              
         :                                                    
 1ses(B) : RVRVPQALIPYMGKEVLEPCG                              
           _____________________                              

Details

  Property   Value
 Conformer 1 1ses(A)
 Conformer 2 1ses(B)
 Radius gyration for conformer 1 27.23 A
 Radius gyration for conformer 2 27.06 A
 EC Number 6.1.1.11  
Click here to see the DynDom results or the famliy
 Trigger ligands AMP423
 Trigger ligands in which conformation Conformation  2
 Conformaton with trigger ligands is compact Yes
 Spanning ligands No
 Residues in enzyme contacting ligands ALA383  ARG256  ARG271  ARG386  GLU258  GLU345  HIS347  LYS277  MET270  PHE275  SER348  THR346  THR380  VAL272 
 Residues in extended bending regions contacting ligands Null
 Residues in extended bending regions making H-bonds or salt-bridges with ligands Null
  Residues in extended bending regions with an H-bond between its main chain and ligands Null
Click here to see the details of H-bonds between ligands and enzyme in PDF format generated by LIGPLOT